4-(1H-indol-3-yl)-1,3-thiazol-2-amine

Base Information

• Chemical Name: 4-(1H-indol-3-yl)-1,3-thiazol-2-amine
• CAS No.: 22258-56-6
• Molecular Formula: C₁₁H₉N₃S
• Molecular Weight: 215.279
• Hs Code.: 2934100090
• DSSTox Substance ID: DTXSID90355536
• Wikidata: Q82134503
• ChEMBL ID: CHEMBL1521813
• Mol file: 22258-56-6.mol

Synonyms:22258-56-6;4-(1H-indol-3-yl)-1,3-thiazol-2-amine;4-(1H-Indol-3-yl)-thiazol-2-ylamine;4-(1H-Indol-3-yl)thiazol-2-amine;MFCD00449605;SMR000063015;Oprea1_091645;Oprea1_375606;MLS000057973;SCHEMBL1800635;CHEMBL1521813;DTXSID90355536;2-amino-4-(indol-3-yl)thiazole;HMS2365A08;BBL010694;STK801736;AKOS000116885;4-(1H-Indol-3-yl)thiazol-2-ylamine;CS-0221101;EU-0073152;FT-0677700;EN300-08345;SR-01000311239;SR-01000311239-1;Z48847568

Chemical Property of 4-(1H-indol-3-yl)-1,3-thiazol-2-amine

Chemical Property:

• Vapor Pressure: 1.61E-10mmHg at 25°C
• Boiling Point: 510°Cat760mmHg
• Flash Point: 262.2°C
• PSA: 82.94000
• Density: 1.414g/cm³
• LogP: 3.45480
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 215.05171847
• Heavy Atom Count: 15
• Complexity: 236

Purity/Quality:

98%min ^*data from raw suppliers

4-(1H-indol-3-yl)-1,3-thiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=CN2)C3=CSC(=N3)N

Technology Process of 4-(1H-indol-3-yl)-1,3-thiazol-2-amine

There total 7 articles about 4-(1H-indol-3-yl)-1,3-thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-chloroacetylindole (28755-03-5) + thiourea (17356-08-0) → 2-amino-4-(indol-3'-yl)thiazole (22258-56-6)

Guidance literature:

Reference yield:

3-acetylindole (703-80-0) + thiourea (17356-08-0) → 2-amino-4-(indol-3'-yl)thiazole (22258-56-6)

Guidance literature:

With iodine; In ethanol; for 24h; Reflux;

Reference yield:

2-bromo-1-(1H-indol-3-yl)ethanone (19611-93-9) + thiourea (17356-08-0) → 2-amino-4-(indol-3'-yl)thiazole (22258-56-6)

Guidance literature:

With copper(ll) bromide; In ethyl acetate; at 100 ℃; for 1h;

DOI:10.3109/14756366.2015.1135912

upstream raw materials:

3-chloroacetylindole

thiourea

indole

3-acetylindole

Downstream raw materials:

[4-(1H-Indol-3-yl)-thiazol-2-yl]-[1-phenyl-meth-(E)-ylidene]-amine

[4-(1H-Indol-3-yl)-thiazol-2-yl]-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-amine

RU114757

[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-[4-(1H-indol-3-yl)-thiazol-2-yl]-amine