2-chloro-N-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]acetamide

Base Information

Chemical Name:2-chloro-N-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]acetamide
CAS No.:19750-29-9
Molecular Formula:C₁₃H₁₀ClN₃OS
Molecular Weight:291.761
Hs Code.:2934100090
ChEMBL ID:CHEMBL5206881
DSSTox Substance ID:DTXSID20585389
Wikidata:Q82477341
Mol file:19750-29-9.mol

Synonyms:19750-29-9;2-chloro-N-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]acetamide;N-(4-(1H-Indol-3-yl)thiazol-2-yl)-2-chloroacetamide;CHEMBL5206881;DTXSID20585389;BDBM50590385;AKOS027379828;UPCMLD0ENAT5583999:001;CS-0242255;EN300-24657;G40021;Z199464142;Acetamide, 2-chloro-N-[4-(1H-indol-3-yl)-2-thiazolyl]-

Suppliers and Price of 2-chloro-N-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
N-(4-(1H-Indol-3-yl)thiazol-2-yl)-2-chloroacetamide 95%+
1g
$ 400.00

American Custom Chemicals Corporation
2-CHLORO-N-[4-(1H-INDOL-3-YL)-1,3-THIAZOL-2-YL]ACETAMIDE 95.00%
1G
$ 852.55

AK Scientific
2-Chloro-N-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]acetamide
5g
$ 1162.00

AK Scientific
2-Chloro-N-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]acetamide
1g
$ 467.00

Total 7 raw suppliers

Chemical Property of 2-chloro-N-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]acetamide

Chemical Property:

PSA：89.51000
LogP:4.11820
XLogP3:2.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:291.0233108
Heavy Atom Count:19
Complexity:344

Purity/Quality:

97% ^*data from raw suppliers

N-(4-(1H-Indol-3-yl)thiazol-2-yl)-2-chloroacetamide 95%+ ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(=CN2)C3=CSC(=N3)NC(=O)CCl

Technology Process of 2-chloro-N-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]acetamide

There total 4 articles about 2-chloro-N-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 23489-36-3
1-(benzofuran-2-yl)-2-bromoethan-1-one

: 22258-56-6
2-amino-4-(indol-3'-yl)thiazole

: 19750-29-9
RU114757

Guidance literature:: With dmap; bromoacetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; at 100 ℃; for 1h; Reflux;
DOI:10.3109/14756366.2015.1135912

Reference yield:

: 19611-93-9
2-bromo-1-(1H-indol-3-yl)ethanone

: 19750-29-9
RU114757

Guidance literature:: Multi-step reaction with 2 steps

1: copper(ll) bromide / ethyl acetate / 1 h / 100 °C

2: bromoacetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / 1,2-dichloro-ethane; N,N-dimethyl-formamide / 1 h / 100 °C / Reflux

With dmap; bromoacetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; copper(ll) bromide; In ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.3109/14756366.2015.1135912

Reference yield:

: 703-80-0
3-acetylindole

: 19750-29-9
RU114757

Guidance literature:: Multi-step reaction with 3 steps

1: copper(ll) bromide / ethyl acetate / 1 h / 100 °C / Reflux

2: copper(ll) bromide / ethyl acetate / 1 h / 100 °C

3: bromoacetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / 1,2-dichloro-ethane; N,N-dimethyl-formamide / 1 h / 100 °C / Reflux

With dmap; bromoacetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; copper(ll) bromide; In ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.3109/14756366.2015.1135912