2,4,5-TRIMETHOXY-BENZOYL CHLORIDE

Base Information

• Chemical Name: 2,4,5-TRIMETHOXY-BENZOYL CHLORIDE
• CAS No.: 42833-66-9
• Molecular Formula: C10H11ClO4
• Molecular Weight: 230.648
• Hs Code.: 2918990090
• Mol file: 42833-66-9.mol

Synonyms:2,4,5-trimethoxybenzoyl chloride;2,4,5-trimethoxybenzoic acid chloride;2,4,5-Trimethoxy-benzoylchlorid;

Chemical Property of 2,4,5-TRIMETHOXY-BENZOYL CHLORIDE

Chemical Property:

• Vapor Pressure: 5.57E-05mmHg at 25°C
• Boiling Point: 346.9oC at 760 mmHg
• Flash Point: 148.2oC
• PSA: 44.76000
• Density: 1.227g/cm3
• LogP: 2.09140

Purity/Quality:

99%, ^*data from raw suppliers

2,4,5-Trimethoxybenzoylchloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Asaronic Chloride is an intermediate in the synthesis of 2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxylic Acid (H972788) which is an impurity of Acotiamide (A190260), an acetylcholinesterase inhibitor which has been shown to stimulate gastric motility and improve gastric motility dysfunction in rats. Acotiamide Hydrochloride has also been shown to improve meal-related symptoms of functional dyspepsia.

Technology Process of 2,4,5-TRIMETHOXY-BENZOYL CHLORIDE

There total 3 articles about 2,4,5-TRIMETHOXY-BENZOYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

asaronic acid (490-64-2) → 2,4,5-trimethoxybenzoyl chloride (42833-66-9)

Guidance literature:

With thionyl chloride; benzene;

Reference yield:

methyl 2,4,5-trimethoxybenzoate (20029-76-9) → 2,4,5-trimethoxybenzoyl chloride (42833-66-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 5percent aq. KOH / 0.5 h / Heating

2: SOCl₂ / benzene / 2 h / Ambient temperature

With potassium hydroxide; thionyl chloride; In benzene;

DOI:10.1021/jo00258a022

Reference yield:

→ 2,4,5-trimethoxybenzoyl chloride (42833-66-9)

Guidance literature:

Benzoic-acid (II), Thionylchloride;

upstream raw materials:

asaronic acid

methyl 2,4,5-trimethoxybenzoate

Downstream raw materials:

2,2',4,4',5,5'-hexamethoxybiphenyl

bis(2,4,5-trimethoxyphenyl)methanone

2,4,5-trimethoxy-N-phenylbenzamide

(2,4,5-trimethoxy-benzoyl)-urea