Quinoline, 1,2,3,4-tetrahydro-2,3-dimethyl-

Base Information

• Chemical Name: Quinoline, 1,2,3,4-tetrahydro-2,3-dimethyl-
• CAS No.: 42836-16-8
• Molecular Formula: C₁₁H₁₅N
• Molecular Weight: 161.247
• Mol file: 42836-16-8.mol

Synonyms:2,3-dimethyl-1,2,3,4-tetrahydro-quinoline;2,3-Dimethyl-1,2,3,4-tetrahydro-chinolin;

Chemical Property of Quinoline, 1,2,3,4-tetrahydro-2,3-dimethyl-

Chemical Property:

• Melting Point: 38 - 39 °C (light petroleum)
• PSA: 12.03000
• LogP: 2.81720

Purity/Quality:

99% ^*data from raw suppliers

CID15645709 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Quinoline, 1,2,3,4-tetrahydro-2,3-dimethyl-

There total 19 articles about Quinoline, 1,2,3,4-tetrahydro-2,3-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

2-Aminobenzyl alcohol (5344-90-1) + iso-butanol (78-92-2,15892-23-6) → 2-ethyl-1,2,3,4-tetrahydroquinoline (42835-88-1) + 2,3-dimethyl-1,2,3,4-tetrahydroquinoline (42836-16-8)

Guidance literature:

iso-butanol; With 2C₂₁H₂₂MnNO₃P⁽¹⁺⁾*Br^(1-)*0.5Br₄Mn^(2-); potassium hydride; at -5 ℃; for 0.0833333h; Inert atmosphere; Glovebox; Sealed tube;

2-Aminobenzyl alcohol; With potassium hydroxide; In 1,2-dimethoxyethane; at 120 ℃; for 24h; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1021/acs.orglett.0c02905

Reference yield: 2.0%

2-(2-methylbutyl)phenyl azide (91337-44-9) → 2-ethyl-2-methyl-2,3-dihydro-1H-indole (88297-76-1) + 2,3-dimethyl-1,2,3,4-tetrahydroquinoline (42836-16-8) + 2-(2-ethylprop-2-en-1-yl)aniline

Guidance literature:

In various solvent(s); at 180 ℃; for 0.5h;

DOI:10.1002/poc.837

Reference yield:

2,3-dimethylquinoline (1721-89-7) → 2,3-dimethyl-1,2,3,4-tetrahydroquinoline (42836-16-8)

Guidance literature:

With ethanol; sodium;

upstream raw materials:

2,3-dimethylquinoline

sulfuric acid

2,3-dimethylquinolin-4-ol

ethanol