3-chloro-N-phenylphthalimide

Base Information

Chemical Name:3-chloro-N-phenylphthalimide
CAS No.:42899-83-2
Molecular Formula:C14H8ClNO2
Molecular Weight:257.676
Hs Code.:
DSSTox Substance ID:DTXSID70455902
Nikkaji Number:J1.937.613C
Wikidata:Q82278062
Mol file:42899-83-2.mol

Synonyms:42899-83-2;4-Chloro-2-phenylisoindoline-1,3-dione;3-chloro-N-phenylphthalimide;n-phenyl-3-chlorophthalimide;SCHEMBL1500541;DTXSID70455902;VVQTYZKVZLDUND-UHFFFAOYSA-N;4-chloro-2-phenyl-2,3-dihydro-1H-isoindole-1,3-dione

Suppliers and Price of 3-chloro-N-phenylphthalimide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 3-chloro-N-phenylphthalimide

Chemical Property:

PSA：37.38000
LogP:3.20560
XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:257.0243562
Heavy Atom Count:18
Complexity:365

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)N2C(=O)C3=C(C2=O)C(=CC=C3)Cl

Technology Process of 3-chloro-N-phenylphthalimide

There total 4 articles about 3-chloro-N-phenylphthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 117-21-5
3-chlorophthalic anhydride

: 62-53-3
aniline

: 42899-83-2
3-chloro-N-phenylphthalimide

Guidance literature:: With acetic acid; at 120 ℃; Inert atmosphere;
DOI:10.1021/acs.orglett.7b03278

Reference yield: 90.0%

: 51108-30-6
4-chloro-1H-isoindole-1,3(2H)-dione

: 591-50-4
iodobenzene

: 42899-83-2
3-chloro-N-phenylphthalimide

Guidance literature:: 4-chloro-1H-isoindole-1,3(2H)-dione; iodobenzene; With sodium t-butanolate; In toluene; for 0.5h; Reflux;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; for 3h; Reflux;

Reference yield:

: 4727-29-1
phthalanilic acid

: 42899-83-2
3-chloro-N-phenylphthalimide

Guidance literature:: Multi-step reaction with 2 steps

1: [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; potassium carbonate; 1-methyl-pyrrolidin-2-one; water / 6 h / 150 °C / Schlenk technique; Inert atmosphere

2: acetic acid / 120 °C / Inert atmosphere

With 1-methyl-pyrrolidin-2-one; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; water; potassium carbonate; acetic acid;
DOI:10.1021/acs.orglett.7b03278