(2R,5S)-tert-butyl 4-benzyl-2,5-diMethylpiperazine-1-carboxylate

Base Information

• Chemical Name: (2R,5S)-tert-butyl 4-benzyl-2,5-diMethylpiperazine-1-carboxylate
• CAS No.: 431062-00-9
• Molecular Formula: C18H28N2O2
• Molecular Weight: 304.433
• Mol file: 431062-00-9.mol

Synonyms:(2R,5S)-tert-butyl 4-benzyl-2,5-diMethylpiperazine-1-carboxylate;

Chemical Property of (2R,5S)-tert-butyl 4-benzyl-2,5-diMethylpiperazine-1-carboxylate

Chemical Property:

• Boiling Point: 380.7±35.0 °C(Predicted)
• PKA: 7.01±0.70(Predicted)
• PSA: 32.78000
• Density: 1.035±0.06 g/cm3(Predicted)
• LogP: 3.39210

Purity/Quality:

97% ^*data from raw suppliers

(2R,5S)-4-Benzyl-2,5-dimethyl-piperazine-1-carboxylicacidtert-butylester 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,5S)-tert-butyl 4-benzyl-2,5-diMethylpiperazine-1-carboxylate

There total 6 articles about (2R,5S)-tert-butyl 4-benzyl-2,5-diMethylpiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(3S,6R)-4-benzyl-3,6-dimethylpiperazine-2,5-dione (1072102-01-2) + di-tert-butyl dicarbonate (24424-99-5) → 4-benzyl-2R,5S-dimethyl-piperazine-1-carboxylic acid tert-butyl ester (431062-00-9)

Guidance literature:

(3S,6R)-4-benzyl-3,6-dimethylpiperazine-2,5-dione; With lithium aluminium tetrahydride; In tetrahydrofuran; Heating / reflux;

With sodium hydroxide; water; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

di-tert-butyl dicarbonate; In tetrahydrofuran; at 20 ℃;

Reference yield: 60.0%

di-tert-butyl dicarbonate (24424-99-5) + (-)-(2R,5S)-1-benzyl-2,5-dimethylpiperazine (216532-43-3,3138-88-3,324750-43-8,745031-35-0) → 4-benzyl-2R,5S-dimethyl-piperazine-1-carboxylic acid tert-butyl ester (431062-00-9)

Guidance literature:

With trimethylamine; In tetrahydrofuran; at 20 ℃; for 5.75h; Cooling with ice;

Reference yield:

benzyl bromide (100-39-0) → 4-benzyl-2R,5S-dimethyl-piperazine-1-carboxylic acid tert-butyl ester (431062-00-9)

Guidance literature:

(2R,5S)-2,5-dimethyl-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; With sodium hydride; In DMF (N,N-dimethyl-formamide); for 0.25h;

benzyl bromide; In DMF (N,N-dimethyl-formamide);

upstream raw materials:

benzyl bromide

(3S,6R)-4-benzyl-3,6-dimethylpiperazine-2,5-dione

di-tert-butyl dicarbonate

(-)-(2R,5S)-1-benzyl-2,5-dimethylpiperazine

Downstream raw materials:

4-(((2R,5S)-4-benzyl-2,5-dimethylpiperazin-1-yl)methyl)tetrahydro-2H-pyran-4-ol

(2R,5S)-2,5-dimethyl-1-piperazinecarboxylic acid 1,1-dimethylethyl ester

trans-2R,5S-dimethyl-4-benzyl-piperazine