(2R,5S)-tert-butyl 4-benzyl-2,5-diMethylpiperazine-1-carboxylate

Base Information

Chemical Name:(2R,5S)-tert-butyl 4-benzyl-2,5-diMethylpiperazine-1-carboxylate
CAS No.:431062-00-9
Molecular Formula:C18H28N2O2
Molecular Weight:304.433
Hs Code.:
Mol file:431062-00-9.mol

Synonyms:(2R,5S)-tert-butyl 4-benzyl-2,5-diMethylpiperazine-1-carboxylate;

Suppliers and Price of (2R,5S)-tert-butyl 4-benzyl-2,5-diMethylpiperazine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

J&W Pharmlab
(2R,5S)-4-Benzyl-2,5-dimethyl-piperazine-1-carboxylicacidtert-butylester 96%
5g
$ 3998.00

J&W Pharmlab
(2R,5S)-4-Benzyl-2,5-dimethyl-piperazine-1-carboxylicacidtert-butylester 96%
1g
$ 998.00

J&W Pharmlab
(2R,5S)-4-Benzyl-2,5-dimethyl-piperazine-1-carboxylicacidtert-butylester 96%
500mg
$ 549.00

J&W Pharmlab
(2R,5S)-4-Benzyl-2,5-dimethyl-piperazine-1-carboxylicacidtert-butylester 96%
250mg
$ 325.00

J&W Pharmlab
(2R,5S)-4-Benzyl-2,5-dimethyl-piperazine-1-carboxylicacidtert-butylester 96%
100mg
$ 212.00

J&W Pharmlab
(2R,5S)-4-Benzyl-2,5-dimethyl-piperazine-1-carboxylicacidtert-butylester 96%
50mg
$ 156.00

Total 8 raw suppliers

Chemical Property of (2R,5S)-tert-butyl 4-benzyl-2,5-diMethylpiperazine-1-carboxylate

Chemical Property:

Boiling Point:380.7±35.0 °C(Predicted)
PKA:7.01±0.70(Predicted)
PSA：32.78000
Density:1.035±0.06 g/cm3(Predicted)
LogP:3.39210

Purity/Quality:

97% ^*data from raw suppliers

(2R,5S)-4-Benzyl-2,5-dimethyl-piperazine-1-carboxylicacidtert-butylester 96% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,5S)-tert-butyl 4-benzyl-2,5-diMethylpiperazine-1-carboxylate

There total 6 articles about (2R,5S)-tert-butyl 4-benzyl-2,5-diMethylpiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1072102-01-2
(3S,6R)-4-benzyl-3,6-dimethylpiperazine-2,5-dione

: 24424-99-5
di-tert-butyl dicarbonate

: 431062-00-9
4-benzyl-2R,5S-dimethyl-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: (3S,6R)-4-benzyl-3,6-dimethylpiperazine-2,5-dione; With lithium aluminium tetrahydride; In tetrahydrofuran; Heating / reflux;

With sodium hydroxide; water; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

di-tert-butyl dicarbonate; In tetrahydrofuran; at 20 ℃;

Reference yield: 60.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 216532-43-3,3138-88-3,324750-43-8,745031-35-0
(-)-(2R,5S)-1-benzyl-2,5-dimethylpiperazine

: 431062-00-9
4-benzyl-2R,5S-dimethyl-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: With trimethylamine; In tetrahydrofuran; at 20 ℃; for 5.75h; Cooling with ice;

Reference yield:

: 100-39-0
benzyl bromide

: 431062-00-9
4-benzyl-2R,5S-dimethyl-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: (2R,5S)-2,5-dimethyl-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; With sodium hydride; In DMF (N,N-dimethyl-formamide); for 0.25h;

benzyl bromide; In DMF (N,N-dimethyl-formamide);