1,3-Di-(5-carbomethoxyamyl) urea

Base Information

• Chemical Name: 1,3-Di-(5-carbomethoxyamyl) urea
• CAS No.: 6621-60-9
• Molecular Formula: C₁₅H₂₈N₂O₅
• Molecular Weight: 316.398
• Hs Code.: 2924199090
• Mol file: 6621-60-9.mol

Synonyms:Hexanoicacid, 6,6'-ureylenedi-, dimethyl ester (6CI,7CI); NSC 59785

Chemical Property of 1,3-Di-(5-carbomethoxyamyl) urea

Chemical Property:

• Vapor Pressure: 6.88E-09mmHg at 25°C
• Boiling Point: 466.8°C at 760 mmHg
• Flash Point: 236.1°C
• PSA: 93.73000
• Density: 1.062g/cm³
• LogP: 2.53420

Purity/Quality:

1,3-BIS(5-(CARBOMETHOXY)PENTYL)UREA Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Di-(5-carbomethoxyamyl) urea

There total 8 articles about 1,3-Di-(5-carbomethoxyamyl) urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

methyl 6-aminohexanoate hydrochloride (2780-89-4) + 1,1'-carbonyldiimidazole (530-62-1) → N,N'-bis(5-methoxycarbonylpent-1-yl)urea (6621-60-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 41h; Inert atmosphere;

DOI:10.1016/j.bmc.2013.01.017

Reference yield: 44.0%

dicobalt octacarbonyl (15226-74-1,61091-28-9,61117-58-6) + methyl 6-aminohexanoate hydrochloride (2780-89-4) → N,N'-bis(5-methoxycarbonylpent-1-yl)urea (6621-60-9)

Guidance literature:

With triethylamine; In acetonitrile; at 100 ℃; for 0.75h; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.bmc.2013.01.017

Reference yield:

6,6'-thioureylene-di-hexanoic acid (6630-05-3) → N,N'-bis(5-methoxycarbonylpent-1-yl)urea (6621-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous H₂O₂

2: H₂SO₄

With sulfuric acid; dihydrogen peroxide;

DOI:10.1021/ja01539a058

upstream raw materials:

methanol

6,6'-ureylenedihexanoic acid

methyl 6-isocyanatohexanoate

6,6'-thioureylene-di-hexanoic acid

Downstream raw materials:

6,6'-ureylene-di-hexanoic acid bis-benzylamide

N,N'-bis-(5-benzylcarbamoyl-pentyl)-N-nitroso-urea