Methanol

Base Information

• Chemical Name: Methanol
• CAS No.: 67-56-1
• Deprecated CAS: 54841-71-3,1173023-83-0,1196157-60-4,1173023-83-0
• Molecular Formula: CH4O
• Molecular Weight: 32.0422
• Hs Code.: 2905 11 00
• European Community (EC) Number: 200-659-6
• ICSC Number: 0057
• NSC Number: 85232
• UN Number: 1230
• UNII: Y4S76JWI15
• DSSTox Substance ID: DTXSID2021731
• Nikkaji Number: J2.287.162E,J2.364G
• Wikipedia: Methanol
• Wikidata: Q14982,Q27115113,Q83051206
• NCI Thesaurus Code: C217
• RXCUI: 1310568
• Metabolomics Workbench ID: 51042
• ChEMBL ID: CHEMBL14688
• Mol file: 67-56-1.mol

Synonyms:Alcohol, methyl;Carbinol;Methanol cluster;Bieleski's solution;Methyl alcohol;Wood alcohol;

Chemical Property of Methanol

Chemical Property:

• Appearance/Colour: Clear, colorless liquid
• Vapor Pressure: 410 mm Hg ( 50 °C)
• Melting Point: -98 °C(lit.)
• Refractive Index: n20/D 1.329(lit.)
• Boiling Point: 48.093 °C at 760 mmHg
• PKA: 15.2(at 25℃)
• Flash Point: 11.111 °C
• PSA: 20.23000
• Density: 0.753 g/cm³
• LogP: -0.39150
• Storage Temp.: Store at RT.
• Solubility.: benzene: miscible(lit.)
• Water Solubility.: miscible
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 32.026214747
• Heavy Atom Count: 2
• Complexity: 2
• Transport DOT Label: Flammable Liquid Poison (international)

Purity/Quality:

99% ^*data from raw suppliers

Methanol anhydrous, 99.8% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, T, F
• Hazard Codes: Xn,T,F
• Statements: 10-20/21/22-68/20/21/22-39/23/24/25-23/24/25-11-40-36-36/38-23/25
• Safety Statements: 36/37-7-45-16-24/25-23-24-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Solvents -> Alcohols (
• Canonical SMILES: CO
• Inhalation Risk: A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20 °C.
• Effects of Short Term Exposure: The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. This may result in loss of consciousness. Exposure could cause blindness and death. The effects may be delayed. Medical observation is indicated.
• Effects of Long Term Exposure: Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the central nervous system. This may result in persistent or recurring headaches and impaired vision.
• Uses: Methanol is an important chemical raw material for fine chemicals. Its carbonylation at 3.5 MPa and 180-200° C in the presence of catalyst can produce acetic acid and further produce acetic anhydride. It reacts with syngas to prepare vinyl acetate in the presence of catalyst; reacts with isobutylene to produce tert-butyl methyl ether; prepare dimethyl oxalate through oxidization and carbonylation, and a further hydrogenation to produce ethylene glycol; reacts with toluene under catalyst and simultaneous oxidization to produce phenylethyl alcohol. It can be used as a good solvent, as a pesticide raw material, as an antifreeze agent, as a fuel and fuel additive (this is receiving increasing attention in environmental protection field). It is the main raw material in the preparation of formaldehyde, the raw material in medicine and spices production, a solvent in dyes and paint industries, the raw material in preparation of methanol single cell protein and synthesis of methyl ester. ▼▲ Industry Applications Role/Benefit Laboratory HPLC, UV/VIS spectroscopy, and LCMS Low UV cutoff Chemical manufacture Production of formaldehyde and its derivates Main feedstock Production of hydrocarbon chains and even aromatic systems Main feedstock Production of methyl tert-butyl ether Methylation reagent Production of dimethyl terephthalic acid, methyl methacrylate and acrylic acid methyl ester Main feedstock Plastics Production of polymers Main feedstock Farm chemical Production of insecticide and acaricide Main feedstock Pharmaceuticals Production of sulfonamides, amycin, etc Main feedstock Fuel for vehicles Pure methanol fuel Pure methanol does not produce an opaque cloud of smoke in the event of an accident Methanol gasoline Blended directly into gasoline to produce a high-octane, efficient fuel with lower emissions than conventional gasoline Chemical analysis Determination of boron Analysis agent Determination of trace moisture in alcohols, saturated hydrocarbons, benzene, chloroform, pyridine Analysis agent Others Separation of calcium sulfate and magnesium sulfate Separation reagent Separation of strontium bromide and barium bromide Separation reagent Anti-freezing agent Effective component Methanol has numerous uses. Its main use is in the production of formaldehyde, whichconsumes approximately 40% of methanol supplies. Methanolis a common organic solvent found in many products including deicers (windshield wiperfl uid), antifreezes, correction fl uid, fuel additives, paints, and other coatings. A number ofindustrial chemicals use methanol in their production. Among these are methyl methacrylateand dimethyl terephthalate. Methanol is used to convert methylacrylamide sulfate to methylmethacrylate and ammonium hydrogen sulfate (NH4HSO4):Methanol is used in making the ester dimethyl terephthalate from mixtures ofxylene of toluene. Dimethyl terephthalate is used in the manufacture of polyesters and plastics.Methanol is used as a fuel additive. The common gasoline additive HEET is pure methanoland is used as a gas-line antifreeze and water remover. Methanol is used as a fuel in camp stoves and small heating devices. It is used to fuel the small engines used in models (airplanes,boats). In the early history of automobiles,methanol was a common fuel. The availability of cheap gasoline replaced methanol in the1920s, but it is receiving renewed interest as an alternative fuel as the demand and cost of oilincrease and oil supplies become uncertain. Methanol can be produced from coal and biomass.Methanol has a higher octane rating and generally lower pollutant emissions compared togasoline. The relatively low flame temperature means that fewer nitrogen oxides are producedby methanol than by ethanol. One large disadvantage of methanol is that it has a lower energydensity than gasoline. Using equivalent volumes of gasoline and methanol, methanol givesabout half the mileage of gasoline. Another problem with methanol is its low vapor pressure,resulting in starting problems on cold days. This problem can be mitigated by using a blendof 85% methanol and 15% gasoline. This mixture is called M85 and is similar to E85 ethanol(see Ethyl Alcohol). Methanol is used in the production offormaldehyde, acetic acid, methyl tert-butylether, and many chemical intermediates; asan octane improver (in oxinol); and as apossible alternative to diesel fuel; being anexcellent polar solvent, it is widely used as acommon laboratory chemical and as a methylating reagent. high purity grade for ICP-MS detection Methylalcohol, CH30H, also known as methanol or wood alcohol, is a colorless, toxic, flammable liquid with a boiling point of 64.6 °C(147 °F). The principal toxic effect is on the nervous system,particularly the retinae. Methyl alcoholis miscible in all proportions with water,ethyl alcohol, and ether. It burns with a light blue flame producing water and carbon dioxide. This vapor forms an explosive mixture(6.0 to 36.5% by volume) with air. Methyl alcohol is an important inexpensive raw material that is synthetically produced for the organic chemical industry. Nearly half of the methyl alcohol manufactured is used in the production of formaldehyde. Other uses of methyl alcohol are as an antifreeze and fuel for automobiles and as an intermediate in the production of synthetic protein. Industrial solvent. Raw material for making formaldehyde and methyl esters of organic and inorganic acids. Antifreeze for automotive radiators and air brakes; ingredient of gasoline and diesel oil antifreezes. Octane booster in gasoline. As fuel for picnic stoves and soldering torches. Extractant for animal and vegetable oils. To denature ethanol. Softening agent for pyroxylin plastics. Solvent and solvent adjuvant for polymers. Solvent in the manufacture of cholesterol, streptomycin, vitamins, hormones, and other pharmaceuticals.
• Description: Methyl alcohol, also known as methanol or wood alcohol, is a clear, colorless, flammable liquid that is the simplest alcohol.World production of methanol is approximately 8.5 billion gallons annually. Methanol is produced industrially, starting with the production of synthesis gas or syngas. Syngas used in the production of methyl alcohol is a mixture of carbon monoxide and hydrogen formed when natural gas reacts with steam or oxygen. Methyl alcohol is then synthesized from carbon monoxide and hydrogen.Methyl alcohol is poisonous and is commonly used to denature ethyl alcohol. Methanol poisoning results from ingestion, inhalation of methanol vapors, or absorption through the skin. Methanol is transformed in the body to formaldehyde (H2CO) by the enzyme alcohol dehydrogenase.The formaldehyde is then metabolized to formic acid (HCOOH)by aldehyde dehydrogenase.
• Physical properties: Clear, colorless liquid with a characteristic alcoholic odor. Odor threshold concentrations ranged from 8.5 ppbv (Nagata and Takeuchi, 1990) to 100.0 ppmv (Leonardos et al., 1969). Experimentally determined detection and recognition odor threshold concentrations were 5.5 mg/m3 (4.2 ppmv) and 69 mg/m3 (53 ppmv), respectively (Hellman and Small, 1974).

Technology Process of Methanol

There total 2805 articles about Methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.6%

Dimethoxymethane (109-87-5) + toluene (108-88-3,15644-74-3,16713-13-6) → styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + methanol (67-56-1) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + ethylbenzene (100-41-4,27536-89-6)

Guidance literature:

Cs exchanged boron doped zeolite 13X; at 400 ℃; Further byproducts given;

Reference yield:

ethanol (64-17-5) + Trimethylmethoxysilane (1825-61-2) → methanol (67-56-1) + ethyl trimethylsilyl ether (1825-62-3)

Guidance literature:

at 21.9 ℃; Equilibrium constant;

Reference yield:

1-Methoxy-4-(1-methoxy-vinyl)-benzene (51440-56-3) → methanol (67-56-1) + 1-(4-methoxyphenyl)ethanone (100-06-1)

Guidance literature:

With water; at 25 ℃; calculated const. and ΔG for the isodesmic equilibra;

DOI:10.1016/S0040-4039(00)96002-7

upstream raw materials:

benzoic acid methyl ester

sodium methylate

tert.-butylhydroperoxide

peracetic acid

Downstream raw materials:

7-O-methylsalicin tetraacetate

methyl 2,3,4-tri-O-acetyl-6-O-p-toluenesulfonyl-β-D-galactopyranoside

methyl 2,3,4-tri-O-benzoyl-β-D-ribopyranoside

(2S,3S,4R,5R)-2-Methoxy-tetrahydro-pyran-3,4,5-triol

Refernces

• 1、 Kumar, Pawan,Chauhan,Sain, Bir,Jain, Suman L.. "Photo-induced reduction of CO2 using a magnetically separable Ru-CoPc@TiO2@SiO2@Fe3O4 catalyst under visible light irradiation". . p. 4546 - 4553. Retrieved 2015.
• 2、 Iijima, Go,Kitagawa, Tatsuya,Katayama, Akira,Inomata, Tomohiko,Yamaguchi, Hitoshi,Suzuki, Kazunori,Hirata, Kazuki,Hijikata, Yoshimasa,Ito, Miho,Masuda, Hideki. "CO2 Reduction Promoted by Imidazole Supported on a Phosphonium-Type Ionic-Liquid-Modified Au Electrode at a Low Overpotential". . p. 1990 - 2000. Retrieved 2018.
• 3、 Patart. "". . p. 1330. Retrieved 1924.
• 4、 Morikawa, Motoharu,Ogura, Yuta,Ahmed, Naveed,Kawamura, Shogo,Mikami, Gaku,Okamoto, Seiji,Izumi, Yasuo. "Photocatalytic conversion of carbon dioxide into methanol in reverse fuel cells with tungsten oxide and layered double hydroxide photocatalysts for solar fuel generation". . p. 1644 - 1651. Retrieved 2014.
• 5、 Rasmussen, Christian Lund,Geest Jakobsen,Glarborg, Peter. "Experimental measurements and kinetic modeling of CH4/O 2 and CH4/C2H6/02 conversion at high pressure". . p. 778 - 807. Retrieved 2008.
• 6、 Kumar, Pawan,Kumar, Arvind,Sreedhar, Bojja,Sain, Bir,Ray, Siddharth S.,Jain, Suman L.. "Cobalt phthalocyanine immobilized on graphene oxide: An efficient visible-active catalyst for the photoreduction of carbon dioxide". . p. 6154 - 6161. Retrieved 2014.
• 7、 Balasubramanian, P. N.,Lindsay Smith, John R.,Davies, Michael J.,Kaaret, Thomas W.,Bruice, Thomas C.. "Dynamics of Reaction of (meso-Tetrakis(2,6-dimethyl-3-sulfonatophenyl)porphinato)iron(III) Hydrate with tert-Butyl Hydroperoxide in Aqueous Solution. 2. Establishment of a Mechanism That Involves Homolytic O-O Bond Breaking and One-Electron Oxidation of the Iron(III) Porphyrin". . p. 1477 - 1483. Retrieved 1989.
• 8、 Li, Congming,Yuan, Xingdong,Fujimoto, Kaoru. "Development of highly stable catalyst for methanol synthesis from carbon dioxide". . p. 306 - 311. Retrieved 2014.
• 9、 Knorpp, Amy J.,Liu, Zhendong,Mizuno, Stefanie C. M.,Newton, Mark A.,Okubo, Tatsuya,Sushkevich, Vitaly L.,Van Bokhoven, Jeroen A.,Wakihara, Toru,Zhu, Jie. "Cu-Erionite Zeolite Achieves High Yield in Direct Oxidation of Methane to Methanol by Isothermal Chemical Looping". . p. 1448 - 1453. Retrieved 2020.
• 10、 Hofmann,K. A.,Schibsted. "-". . p. 1398. Retrieved 1918.