Technology Process of 1,3,4,6-tetra-O-acetyl-2-[(2-{[(benzyloxy)carbonyl]amino}propanoyl)amino]-2-deoxyhexopyranose
There total 9 articles about 1,3,4,6-tetra-O-acetyl-2-[(2-{[(benzyloxy)carbonyl]amino}propanoyl)amino]-2-deoxyhexopyranose which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-Cbz-Ala;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran;
at 0 ℃;
for 1h;
1,3,4,6-tetra-O-acetyl-D-glucosamine hydrochloride;
With
triethylamine;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 17h;
DOI:10.1039/c4ob01681e
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pyridine
2.1: hydrogenchloride / acetone
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 1 h / 0 °C
3.2: 17 h / 0 - 20 °C
With
pyridine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; acetone;
DOI:10.1039/c4ob01681e
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide
2.1: pyridine
3.1: hydrogenchloride / acetone
4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 1 h / 0 °C
4.2: 17 h / 0 - 20 °C
With
pyridine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide;
In
tetrahydrofuran; acetone;
DOI:10.1039/c4ob01681e
