Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 5,8-dihydro-2-(4-(3-(4-(acetylamino)phenyl)-3-oxopropyl)-1-piperazinyl)-8-ethyl-5-oxo-

Base Information

Chemical Name:Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 5,8-dihydro-2-(4-(3-(4-(acetylamino)phenyl)-3-oxopropyl)-1-piperazinyl)-8-ethyl-5-oxo-
CAS No.:68689-96-3
Molecular Formula:C25H28N6O5
Molecular Weight:492.527
Hs Code.:
DSSTox Substance ID:DTXSID80218823
Wikidata:Q83095741

Synonyms:68689-96-3;Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 5,8-dihydro-2-(4-(3-(4-(acetylamino)phenyl)-3-oxopropyl)-1-piperazinyl)-8-ethyl-5-oxo-;DTXSID80218823

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 5,8-dihydro-2-(4-(3-(4-(acetylamino)phenyl)-3-oxopropyl)-1-piperazinyl)-8-ethyl-5-oxo-

Chemical Property:

Density:1.363g/cm³
XLogP3:-1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:8
Exact Mass:492.21211801
Heavy Atom Count:36
Complexity:878

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN1C=C(C(=O)C2=CN=C(N=C21)N3CCN(CC3)CCC(=O)C4=CC=C(C=C4)NC(=O)C)C(=O)O

Technology Process of Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 5,8-dihydro-2-(4-(3-(4-(acetylamino)phenyl)-3-oxopropyl)-1-piperazinyl)-8-ethyl-5-oxo-

There total 3 articles about Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 5,8-dihydro-2-(4-(3-(4-(acetylamino)phenyl)-3-oxopropyl)-1-piperazinyl)-8-ethyl-5-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 2-{4-[3-(4-Acetylamino-phenyl)-3-oxo-propyl]-piperazin-1-yl}-8-ethyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester; hydrate

: 68689-96-3
2-{4-[3-(4-Acetylamino-phenyl)-3-oxo-propyl]-piperazin-1-yl}-8-ethyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid

Guidance literature:: With sodium carbonate; In ethanol; water; Heating;

Reference yield:

: 3663-97-6
acetic acid-[4-(3-chloro-propionyl)-anilide]

: 68689-96-3
2-{4-[3-(4-Acetylamino-phenyl)-3-oxo-propyl]-piperazin-1-yl}-8-ethyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / triethylamine / propan-2-ol / Heating

2: 63 percent / Na₂CO₃ / ethanol; H₂O / Heating

With sodium carbonate; triethylamine; In ethanol; water; isopropyl alcohol;

Reference yield:

: 51940-43-3
ethyl 5,8-dihydro-8-ethyl-2-(1-piperazinyl)-5-oxopyrido[2,3-d]pyrimidine-6-carboxylate

: 68689-96-3
2-{4-[3-(4-Acetylamino-phenyl)-3-oxo-propyl]-piperazin-1-yl}-8-ethyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / triethylamine / propan-2-ol / Heating

2: 63 percent / Na₂CO₃ / ethanol; H₂O / Heating

With sodium carbonate; triethylamine; In ethanol; water; isopropyl alcohol;