orotic acid hydrazide

Base Information

• Chemical Name: orotic acid hydrazide
• CAS No.: 26409-12-1
• Molecular Formula: C5H6 N4 O3
• Molecular Weight: 170.13
• Hs Code.: 2933599090
• Mol file: 26409-12-1.mol

Synonyms:Oroticacid, hydrazide (6CI,8CI); NSC 34715

Chemical Property of orotic acid hydrazide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 120.84000
• Density: 1.546g/cm³
• LogP: -1.24210

Purity/Quality:

99% ^*data from raw suppliers

2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOHYDRAZIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of orotic acid hydrazide

There total 5 articles about orotic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

ethyl orotate (1747-53-1) → Orotic acid hydrazide (26409-12-1,26696-56-0)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.1515/chem-2020-0096

Reference yield: 45.0%

butyl 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate (22754-37-6) → Orotic acid hydrazide (26409-12-1,26696-56-0)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.1515/chem-2020-0096

Reference yield:

orotic acid (65-86-1,58915-47-2,6784-70-9) → Orotic acid hydrazide (26409-12-1,26696-56-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water / 10 h / Reflux

2: hydrazine hydrate / ethanol / 3 h / Reflux

With hydrogenchloride; hydrazine hydrate; In ethanol; water;

DOI:10.1515/chem-2020-0096

upstream raw materials:

methyl orotate

orotic acid

butyl 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate

ethyl orotate

Downstream raw materials:

α-methyl-2-oxybenzylidene hydrazine of orotic acid

Orotic acid benzylidene hydrazide

orotic 2-oxybenzylidene hydrazide

1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidine-6-carbonyl)-2-(α-methyl-2-oxybenzyl)hydrazine

Refernces