4-Thiazolehexanoic acid, 2-phenyl-, methyl ester

Base Information

Chemical Name:4-Thiazolehexanoic acid, 2-phenyl-, methyl ester
CAS No.:436152-31-7
Molecular Formula:C16H19NO2S
Molecular Weight:289.398
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Thiazolehexanoic acid, 2-phenyl-, methyl ester

Chemical Property:

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Technology Process of 4-Thiazolehexanoic acid, 2-phenyl-, methyl ester

There total 1 articles about 4-Thiazolehexanoic acid, 2-phenyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 2227-79-4
benzenecarbothioamide

: 436152-30-6
methyl 8-bromo-7-oxooctanoate

: 436152-31-7
methyl 6-(2-phenyl-1,3-thiazol-4-yl)hexanoate

Guidance literature:: In methanol; at 20 ℃;
DOI:10.1016/j.bmcl.2003.07.012

Reference yield:

: 436152-31-7
methyl 6-(2-phenyl-1,3-thiazol-4-yl)hexanoate

: 436152-32-8
6-(2-phenyl-1,3-thiazol-4-yl)hexanal

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -78 ℃;
DOI:10.1016/j.bmcl.2003.07.012

Reference yield:

: 436152-31-7
methyl 6-(2-phenyl-1,3-thiazol-4-yl)hexanoate

: 2-oxo-8-(2-phenyl-thiazol-4-yl)-octanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: DIBAL-H / CH₂Cl₂ / -78 °C

2: 95 percent / DBU; LiCl / tetrahydrofuran

3: 64 percent / CsF; AcOH / acetonitrile

With diisobutylaluminium hydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; cesium fluoride; lithium chloride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2003.07.012