N-(2-Dihydroxyborylbenzyl)-N-methylm-tolylamine

Base Information

Chemical Name:N-(2-Dihydroxyborylbenzyl)-N-methylm-tolylamine
CAS No.:436845-46-4
Molecular Formula:C15H18BNO2
Molecular Weight:255.124
Hs Code.:
DSSTox Substance ID:DTXSID80400701
Wikidata:Q82203718
Mol file:436845-46-4.mol

Synonyms:436845-46-4;N-(2-Dihydroxyborylbenzyl)-N-methylm-tolylamine;N-(2-DIHYDROXYBORYLBENZYL)-N-METHYL-M-TOLYLAMINE;DTXSID80400701;AKOS009159349;FT-0704058;(2-{[Methyl(3-methylphenyl)amino]methyl}phenyl)boronic acid

Suppliers and Price of N-(2-Dihydroxyborylbenzyl)-N-methylm-tolylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of N-(2-Dihydroxyborylbenzyl)-N-methylm-tolylamine

Chemical Property:

Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:255.1430590
Heavy Atom Count:19
Complexity:275

Purity/Quality:: 98%Min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:B(C1=CC=CC=C1CN(C)C2=CC=CC(=C2)C)(O)O

Technology Process of N-(2-Dihydroxyborylbenzyl)-N-methylm-tolylamine

There total 4 articles about N-(2-Dihydroxyborylbenzyl)-N-methylm-tolylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 436845-45-3
N-(2-bromobenzyl)-N-methyl-m-tolylamine

: 436845-46-4
N-(2-dihydroxyborylbenzyl)-N-methyl-m-tolylamine

Guidance literature:: N-(2-bromobenzyl)-N-methyl-m-tolylamine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

With Trimethyl borate; In tetrahydrofuran; at -78 - 20 ℃; Further stages.;
DOI:10.1039/b108896c

Reference yield: 25.0%

: 121-43-7,63156-11-6
Trimethyl borate

: 436845-45-3
N-(2-bromobenzyl)-N-methyl-m-tolylamine

: 436845-46-4
N-(2-dihydroxyborylbenzyl)-N-methyl-m-tolylamine

Guidance literature:: With n-butyllithium; In tetrahydrofuran; to N-(2-bromobenzyl)-N-methyl-m-tolylamine in THF at -78°C was added n-BuLi in THf, stirred at -78°C for 1 h, added to THF soln. B(OMe)3 at -78°C under Ar, allowed to warm to room temp.; HCl was added and stirred for 1 h, water was added, aq. phase wasextd. with CH2Cl2, organic layers were combined and dried over MgSO4, solvent was removed in vacuo;
DOI:10.1039/b108896c

Reference yield:

: 696-44-6
N-methyl-m-toluidine

: 436845-46-4
N-(2-dihydroxyborylbenzyl)-N-methyl-m-tolylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / K₂CO₃ / acetonitrile / 4 h / Heating

2.1: n-BuLi / tetrahydrofuran / 1 h / -78 °C

2.2: 25 percent / B(OCH₃)3 / tetrahydrofuran / -78 - 20 °C

With n-butyllithium; potassium carbonate; In tetrahydrofuran; acetonitrile;
DOI:10.1039/b108896c