Cyclopropanol, 1-(phenylmethyl)-, methanesulfonate

Base Information

• Chemical Name: Cyclopropanol, 1-(phenylmethyl)-, methanesulfonate
• CAS No.: 437709-24-5
• Molecular Formula: C11H14O3S
• Molecular Weight: 226.296
• Mol file: 437709-24-5.mol

Synonyms:

Chemical Property of Cyclopropanol, 1-(phenylmethyl)-, methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopropanol, 1-(phenylmethyl)-, methanesulfonate

There total 2 articles about Cyclopropanol, 1-(phenylmethyl)-, methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-benzylcyclopropan-1-ol (119373-39-6) + methanesulfonyl chloride (124-63-0) → 1-phenylmethylcyclopropyl methanesulfonate (437709-24-5)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1002/adsc.200404025

Reference yield:

benzeneacetic acid methyl ester (101-41-7) → 1-phenylmethylcyclopropyl methanesulfonate (437709-24-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / titanium(IV) isopropoxide / tetrahydrofuran; diethyl ether / 0.67 h / 20 °C

2: 92 percent / pyridine / CH₂Cl₂ / 18 h / 20 °C

With pyridine; titanium(IV) isopropylate; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1002/adsc.200404025

Reference yield: 96.0%

1-phenylmethylcyclopropyl methanesulfonate (437709-24-5) → 2-{1-[(methylsulfonyl)oxy]cyclopropyl}acetic acid (832142-14-0)

Guidance literature:

With periodic acid; ruthenium(IV) oxide; In tetrachloromethane; water; acetonitrile; at 40 ℃; for 22h;

DOI:10.1002/adsc.200404025

upstream raw materials:

1-benzylcyclopropan-1-ol

methanesulfonyl chloride

benzeneacetic acid methyl ester

Downstream raw materials:

(2-(chloromethyl)allyl)benzene

(2-(bromomethyl)prop-3-en-1-yl)benzene

2-{1-[(methylsulfonyl)oxy]cyclopropyl}acetic acid