(R)-tert-butyl 2-(2-(benzyloxycarbonylaMino)-2-phenylacetaMido)acetate

Base Information

Chemical Name:(R)-tert-butyl 2-(2-(benzyloxycarbonylaMino)-2-phenylacetaMido)acetate
CAS No.:439088-73-0
Molecular Formula:C22H26N2O5
Molecular Weight:398.459
Hs Code.:
Mol file:439088-73-0.mol

Synonyms:tert-butyl N-((2R)-2-{[(benzyloxy)carbonyl]amino}-2-phenylethanoyl)glycinate;Bicarbamicacid,tert-butyl methyl ester (8CI);1,2-Hydrazinedicarboxylicacid,1,1-dimethylethyl methyl ester (9CI);tert-butyl methyl hydrazine-1,2-dicarboxylate;

Suppliers and Price of (R)-tert-butyl 2-(2-(benzyloxycarbonylaMino)-2-phenylacetaMido)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

ChemScene
(R)-tert-butyl2-(2-(benzyloxycarbonylamino)-2-phenylacetamido)acetate
100mg
$ 330.00

Total 7 raw suppliers

Chemical Property of (R)-tert-butyl 2-(2-(benzyloxycarbonylaMino)-2-phenylacetaMido)acetate

Chemical Property:

Boiling Point:593.2±50.0 °C(Predicted)
PKA:10.57±0.46(Predicted)
PSA：100.71000
Density:1.180±0.06 g/cm3(Predicted)
LogP:4.15670
Solubility.:Dichloromethane;

Purity/Quality:

99% ^*data from raw suppliers

(R)-tert-butyl2-(2-(benzyloxycarbonylamino)-2-phenylacetamido)acetate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (2R)-2-Phenyl-N-[(phenylmethoxy)carbonyl]glycyl-glycine 1,1-Dimethylethyl Ester is an intermediate used in the synthesis of Piperazinedione-carbonyl D-Phenylglycyl-glycine(P480165), which is an impurity of Piperacillin (P479950), a broad spectrum semi-synthetic antibiotic related to Penicillin.

Technology Process of (R)-tert-butyl 2-(2-(benzyloxycarbonylaMino)-2-phenylacetaMido)acetate

There total 1 articles about (R)-tert-butyl 2-(2-(benzyloxycarbonylaMino)-2-phenylacetaMido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: L-glycine tert butyl ester hydrochloride

: 17609-52-8
Z-D-phenylglycine

: 439088-73-0
(R)-N-benzyloxycarbonyl-α-[N-(t-butoxycarbonylmethyl)carbamoyl]benzylamine

Guidance literature:: L-glycine tert butyl ester hydrochloride; Z-D-phenylglycine; With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 0.0833333h; Inert atmosphere;

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In dichloromethane; at 0 - 25 ℃; for 5.25h; Inert atmosphere;

Reference yield: 99.0%

: 439088-73-0
(R)-N-benzyloxycarbonyl-α-[N-(t-butoxycarbonylmethyl)carbamoyl]benzylamine

: 439088-74-1
(R)-α-[N-(t-butoxycarbonylmethyl)carbamoyl]benzylamine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; toluene; at 20 ℃; for 5.5h; under 760.051 Torr;

Reference yield:

: 439088-73-0
(R)-N-benzyloxycarbonyl-α-[N-(t-butoxycarbonylmethyl)carbamoyl]benzylamine

: 1,1-dioxo-3,3-dibutyl-5-phenyl-7-methyl-8-(N-{(R)-α-[N-(carboxymethyl)carbamoyl]benzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepine

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol; toluene / 5.5 h / 18 - 25 °C / 760.05 Torr

2.1: 4-methyl-morpholine / dichloromethane / 0.33 h / 18 - 25 °C / Inert atmosphere

2.2: 1 h / 18 - 25 °C / Inert atmosphere

3.1: formic acid / water / 17 h / 18 - 25 °C / Inert atmosphere

With 4-methyl-morpholine; formic acid; palladium 10% on activated carbon; hydrogen; In ethanol; dichloromethane; water; toluene;