ert-butyl N-(3-chlorophenyl)carbamate

Base Information

• Chemical Name: ert-butyl N-(3-chlorophenyl)carbamate
• CAS No.: 5330-63-2
• Molecular Formula: C11H14ClNO2
• Molecular Weight: 227.691
• Hs Code.: 2924299090
• Mol file: 5330-63-2.mol

Synonyms:3-chloro-NHBoc-aniline;3-Cl-Ph-NH2;(3-chlorophenyl)-carbamic acid tert-butyl ester;tert-butyl(3-chlorophenyl)carbamate;N-(tert-butoxycarbonyl)-3-chloroaniline;

Chemical Property of ert-butyl N-(3-chlorophenyl)carbamate

Chemical Property:

• Vapor Pressure: 0.0101mmHg at 25°C
• Boiling Point: 263.8°C at 760 mmHg
• Flash Point: 113.4°C
• PSA: 38.33000
• Density: 1.195g/cm³
• LogP: 3.76000

Purity/Quality:

98%min ^*data from raw suppliers

tert-butyl3-chlorophenylcarbamate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ert-butyl N-(3-chlorophenyl)carbamate

There total 10 articles about ert-butyl N-(3-chlorophenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-chloro-aniline (108-42-9) → t-butyl 3-chlorophenylcarbamate (5330-63-2)

Guidance literature:

In methanol; at 100 ℃; for 6h;

DOI:10.1021/jo502581p

Reference yield: 100.0%

→ t-butyl 3-chlorophenylcarbamate (5330-63-2)

Guidance literature:

With guanidine hydrochloride; In ethanol; at 38 ℃;

Reference yield: 88.0%

tert-butyl (3-chlorobenzoyl)oxycarbamate → t-butyl 3-chlorophenylcarbamate (5330-63-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; In chlorobenzene; at 120 ℃; for 2.5h; regioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.6b02724

upstream raw materials:

di-tert-butyl dicarbonate

3-chloro-aniline

tert-butyl 3-chlorophenyl(3-perfluorooctylpropoxy)carbamate

tert-Butyl N-hydroxycarbamate

Downstream raw materials:

3-chloro-N-methylaniline

3-chloro-aniline

N-(3-chlorophenyl)-2-phenylacetamide

N-(3-chlorophenyl)-2-oxo-2-phenylacetamide

Refernces

• 1、 Ananin, Aleksei V.,Kraus, George A.. "Anionic Fries rearrangement of aryl carbonates. A facile route to ortho-hydroxy esters". supporting information. . Retrieved 2020/10/13.
• 2、 -. "Amidate compound, catalyst for polyurethane production, and method for producing polyurethane resin". Page/Page column 124. . Retrieved 2020/07/09.