2-(2,4-difluorophenyl)-4-dimethylaminopyridine

Base Information

• Chemical Name: 2-(2,4-difluorophenyl)-4-dimethylaminopyridine
• CAS No.: 441072-26-0
• Molecular Formula: C13H12F2N2
• Molecular Weight: 234.24500
• Mol file: 441072-26-0.mol

Synonyms:

Chemical Property of 2-(2,4-difluorophenyl)-4-dimethylaminopyridine

Chemical Property:

• Vapor Pressure: 0.000135mmHg at 25°C
• Boiling Point: 333.6oC at 760 mmHg
• Flash Point: 155.6oC
• PSA: 16.13000
• Density: 1.205g/cm3
• LogP: 3.09280

Purity/Quality:

2-(2,4-DIFLUOROPHENYL)-4-DIMETHYLAMINOPYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2,4-difluorophenyl)-4-dimethylaminopyridine

There total 4 articles about 2-(2,4-difluorophenyl)-4-dimethylaminopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2,4-difluorophenylboronic acid (144025-03-6) + (2-iodo-pyridin-4-yl)-dimethyl-amine (396092-83-4) → 2-(2,4-difluorophenyl)-4-N,N-dimethylaminopyridine (441072-26-0)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; toluene; at 90 ℃; for 48h;

Reference yield: 72.0%

2,4-difluorophenylboronic acid (144025-03-6) + 2-bromo-4-(N,N-dimethylamino)pyridine (396092-82-3) → 2-(2,4-difluorophenyl)-4-N,N-dimethylaminopyridine (441072-26-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; barium hydroxide octahydrate; In 1,4-dioxane; water; for 30h; Inert atmosphere; Reflux;

DOI:10.1021/jo4012514

Reference yield:

2,4-dibromopyridine (58530-53-3) → 2-(2,4-difluorophenyl)-4-N,N-dimethylaminopyridine (441072-26-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethanol / 5 h / 50 °C

2.1: barium hydroxide octahydrate / water; 1,4-dioxane / 0.5 h

2.2: 3 h / 120 °C / Microwave irradiation

With barium hydroxide octahydrate; In 1,4-dioxane; ethanol; water;

DOI:10.1021/jacs.1c11667

upstream raw materials:

2,4-difluorophenylboronic acid

(2-iodo-pyridin-4-yl)-dimethyl-amine

1,4-dioxane

water

Refernces

• 1、 Park, Hea Jung,Kim, Ji Na,Yoo, Hyun-Ji,Wee, Kyung-Ryang,Kang, Sang Ook,Cho, Dae Won,Yoon, Ung Chan. "Rational design, synthesis, and characterization of deep blue phosphorescent Ir(III) complexes containing (4′-Substituted-2′- pyridyl)-1,2,4-triazole ancillary ligands". . p. 8054 - 8064. Retrieved 2013/09/12.
• 2、 -. "Light-Emitting Material". . . Retrieved 2009/08/18.