Methyl 8-bromo-6-fluoro-4-oxo-1,4-dihydroquinoline-2-carboxylate

Base Information

• Chemical Name: Methyl 8-bromo-6-fluoro-4-oxo-1,4-dihydroquinoline-2-carboxylate
• CAS No.: 442549-68-0
• Molecular Formula: C₁₁H₇BrFNO₃
• Molecular Weight: 300.084
• Hs Code.: 2933499090
• Mol file: 442549-68-0.mol

Synonyms:Methyl 8-bromo-6-fluoro-4-oxo-1,4-dihydroquinoline-2-carboxylate;8-bromo-6-fluoro-4-oxo-1,4-dihydroquinoline-2-carboxylic acid methyl ester;

Chemical Property of Methyl 8-bromo-6-fluoro-4-oxo-1,4-dihydroquinoline-2-carboxylate

Chemical Property:

• PSA: 59.16000
• LogP: 2.21630
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl8-bromo-6-fluoro-4-oxo-1,4-dihydroquinoline-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 8-bromo-6-fluoro-4-oxo-1,4-dihydroquinoline-2-carboxylate

There total 3 articles about Methyl 8-bromo-6-fluoro-4-oxo-1,4-dihydroquinoline-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-(2-bromo-4-fluorophenylamino)but-2-enedioic acid dimethyl ester (919794-32-4) → 8-bromo-6-fluoro-1H-quinolin-4-one + 8-bromo-6-fluoro-4-oxo-1,4-dihydroquinoline-2-carboxylic acid methyl ester (442549-68-0)

Guidance literature:

With diphenyl ether-biphenyl eutectic; at 250 ℃; for 1h;

DOI:10.1016/j.bmc.2006.10.037

Reference yield:

2-bromo-4-fluoroaniline (1003-98-1) → 8-bromo-6-fluoro-4-oxo-1,4-dihydroquinoline-2-carboxylic acid methyl ester (442549-68-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / methanol / 18 h / Heating

2: 78 percent / DowTherm A / 1 h / 250 °C

With diphenyl ether-biphenyl eutectic; In methanol;

DOI:10.1016/j.bmc.2006.10.037

Reference yield:

dimethyl acetylenedicarboxylate (762-42-5) → 8-bromo-6-fluoro-4-oxo-1,4-dihydroquinoline-2-carboxylic acid methyl ester (442549-68-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / methanol / 18 h / Heating

2: 78 percent / DowTherm A / 1 h / 250 °C

With diphenyl ether-biphenyl eutectic; In methanol;

DOI:10.1016/j.bmc.2006.10.037

upstream raw materials:

2-(2-bromo-4-fluorophenylamino)but-2-enedioic acid dimethyl ester

2-bromo-4-fluoroaniline

dimethyl acetylenedicarboxylate

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