3-amino-4-(methoxymethyl)-6-methyl-N,N-diphenylthieno[2,3-b]pyridine-2-carboxamide

Base Information

• Chemical Name: 3-amino-4-(methoxymethyl)-6-methyl-N,N-diphenylthieno[2,3-b]pyridine-2-carboxamide
• CAS No.: 443332-83-0
• Molecular Formula: C23H21N3O2S
• Molecular Weight: 403.49700
• Mol file: 443332-83-0.mol

Synonyms:3-amino-4-methoxymethyl-6-methylthieno[2,3-b]pyridine-2-carboxylic acid diphenylamide;N,N-diphenyl-3-amino-4-methoxymethyl-6-methylthieno[2,3-b]pyridine-2-carboxamide;3-Amino-4-methoxymethyl-6-methyl-thieno[2,3-b]pyridine-2-carboxylic acid diphenylamide;

Chemical Property of 3-amino-4-(methoxymethyl)-6-methyl-N,N-diphenylthieno[2,3-b]pyridine-2-carboxamide

Chemical Property:

• Melting Point: 185 - 186 °C
• PSA: 96.69000
• LogP: 5.89300

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-amino-4-(methoxymethyl)-6-methyl-N,N-diphenylthieno[2,3-b]pyridine-2-carboxamide

There total 1 articles about 3-amino-4-(methoxymethyl)-6-methyl-N,N-diphenylthieno[2,3-b]pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-chloro-N,N-diphenylacetamide (5428-43-3) + 4-(methoxymethyl)-6-methyl-3-cyanopyridine-2(1H)-thione (31681-83-1) → N,N-diphenyl-3-amino-4-methoxymethyl-6-methylthieno[2,3-b]pyridine-2-carboxamide (443332-83-0)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; at 80 - 85 ℃; for 6h;

DOI:10.1007/s10593-005-0104-9

Reference yield: 97.0%

N,N-diphenyl-3-amino-4-methoxymethyl-6-methylthieno[2,3-b]pyridine-2-carboxamide (443332-83-0) → N,N-diphenyl-3-azido-4-methoxymethyl-6-methylthieno[2,3-b]pyridine-2-carboxamide (496865-48-6)

Guidance literature:

N,N-diphenyl-3-amino-4-methoxymethyl-6-methylthieno[2,3-b]pyridine-2-carboxamide; With sulfuric acid; sodium nitrite; In acetic acid; at 5 - 9 ℃; for 0.333333h;

With sodium azide; In acetic acid; for 1h;

DOI:10.1007/s10593-005-0104-9

Reference yield: 88.0%

cis,trans-2,5-dimethoxytetrahydrofuran (696-59-3) + N,N-diphenyl-3-amino-4-methoxymethyl-6-methylthieno[2,3-b]pyridine-2-carboxamide (443332-83-0) → N,N-diphenyl-4-methoxymethyl-6-methyl-3-(1-pyrrolyl)thieno[2,3-b]pyridine-2-carboxamide

Guidance literature:

With acetic acid; Heating;

DOI:10.1023/A:1023947717729

upstream raw materials:

2-chloro-N,N-diphenylacetamide

4-(methoxymethyl)-6-methyl-3-cyanopyridine-2(1H)-thione

Downstream raw materials:

N,N-diphenyl-3-azido-4-methoxymethyl-6-methylthieno[2,3-b]pyridine-2-carboxamide