2,5-Dimethoxytetrahydrofuran

Base Information

• Chemical Name: 2,5-Dimethoxytetrahydrofuran
• CAS No.: 696-59-3
• Molecular Formula: C6H12O3
• Molecular Weight: 132.159
• Hs Code.: 29321900
• European Community (EC) Number: 211-797-1
• NSC Number: 7911
• DSSTox Substance ID: DTXSID10862378
• Nikkaji Number: J37.038J
• Mol file: 696-59-3.mol

Synonyms:2,5-Dimethoxytetrahydrofuran;696-59-3;Tetrahydro-2,5-dimethoxyfuran;2,5-dimethoxyoxolane;Furan, tetrahydro-2,5-dimethoxy-;Dimethoxytetrahydrofuran;2.5-dimethoxytetrahydrofuran;2,5 dimethoxy tetrahydrofuran;2,5-dimethoxy-tetrahydrofuran;Dimethoxytetrahydrofuran (VAN);NSC 7911;EINECS 211-797-1;AI3-61757;EC 211-797-1;2,5-Bis(methyloxy)tetrahydrofuran;MFCD00005359;2,5-dimethoxy tetrahydrofuran;Protectol DMT;Furan,5-dimethoxy-;DMTHF;2,5-dimethoxytetrahyrofuran;2,5 dimethoxytetrahydrofuran;SCHEMBL58448;2.5-dimethoxytetrahydrofurane;2,5-dimethoxytetra-hydrofuran;2,5-dimethoxy-tetrahydrofurane;2,5-dimethoxy tetrahydro furan;2,5-dimethoxy-tetrahydro-furan;2,5-Dimethoxytetrahydrofuran,c&t;DTXSID10862378;NSC7911;2,5-bis(methyloxy)tetrahydrofuran;AMY19203;NSC-7911;STL194266;AKOS000119966;cis,trans-2,5-Dimethoxytetrahydrofuran;CS-W020517;AC-15670;AS-11451;2,5-Dimethoxytetrahydrofuran, cis + trans;D0986;FT-0610413;EN300-19750;D77900;J-507353;F0001-1807;tetrahydro-2,5-dimethoxy-fura, 2,5-Dimethoxy Tetrahydrofulan, DIMETHOXYTETRAHYDROFURAN

Chemical Property of 2,5-Dimethoxytetrahydrofuran

Chemical Property:

• Appearance/Colour: Colorless to light yellow liquid
• Vapor Pressure: 6.06mmHg at 25°C
• Melting Point: -45 °C
• Refractive Index: n20/D 1.418
• Boiling Point: 145.7 °C at 760 mmHg
• Flash Point: 35 °C
• PSA: 27.69000
• Density: 1.02 g/cm³
• LogP: 0.74180
• Storage Temp.: Flammables area
• Sensitive.: Air & Light Sensitive
• Solubility.: 300g/l
• Water Solubility.: 350 g/L (20 ºC)
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 132.078644241
• Heavy Atom Count: 9
• Complexity: 74.4

Purity/Quality:

95%min, 98% min.99%min(HPLC) ^*data from raw suppliers

2,5-Dimethoxytetrahydrofuran ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xi,Xn
• Statements: 10-36/37/38-36-20/21
• Safety Statements: 26-36-36/37/39-16

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1CCC(O1)OC
• Uses: 2,5-Dimethoxytetrahydrofuran is a tetrahydrofuran derivative that finds application in proteomics research and in organic synthesis. It is also used as an intermediate for atropine sulfate, which is an anticholinergic drug. Further, it acts as a precursor of butanediol. In addition to this, it is used as a photographic hardener and as disinfectant in formulations.

Technology Process of 2,5-Dimethoxytetrahydrofuran

There total 7 articles about 2,5-Dimethoxytetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

methanol (67-56-1) + (1E,3E)-1,4-Bis-trimethylsilanyloxy-buta-1,3-diene (79668-89-6) → cis,trans-2,5-dimethoxytetrahydrofuran (696-59-3)

Guidance literature:

With hydrogenchloride; at -70 - -65 ℃;

DOI:10.1016/S0040-4039(00)78703-X

Reference yield:

methanol (67-56-1) + cyclohexa-1,3-diene (1165952-91-9) → cis,trans-2,5-dimethoxytetrahydrofuran (696-59-3) + succinaldehyde bis(dimethyl acetal) (6922-39-0) + 4,4-dimethoxybutanal (56681-97-1)

Guidance literature:

With 2,3-dimercapto-succinic acid; ozone; Yield given. Multistep reaction. Yields of byproduct given; 1) -78 deg C;

DOI:10.1021/jo00311a021

Reference yield:

→ cis,trans-2,5-dimethoxytetrahydrofuran (696-59-3)

Guidance literature:

upstream raw materials:

2,5-dihydro-2,5-dimethoxyfuran

(2S,5S)-2,5-Dimethoxy-2,5-dihydro-furan

methanol

(1E,3E)-1,4-Bis-trimethylsilanyloxy-buta-1,3-diene

Downstream raw materials:

N-methylcarbazole

2,3-Bis-[1-furan-2-yl-meth-(E)-ylidene]-succinaldehyde

2-(1H-pyrrol-1-yl)pyridine

methyl 4-chloro-2-(1H-pyrrol-1-yl)benzoate

Refernces

• 1、 -. "Agrochemical compositions and methods employing hymexazol and 1,2-benzisothiazolin-3-one". . . Retrieved 2008/06/13.
• 2、 Griesbaum, Karl,Jung, In Chang,Mertens, Henri. "Difunctional and Hetercyclic Prducts from the Ozonolysis of Conjugated C5-C8 Cyclodienes". . p. 6024 - 6027. Retrieved 2007/10/02.