3-(4-chlorophenyl)-5-phenyl-2-thioxo-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-one

Base Information

• Chemical Name: 3-(4-chlorophenyl)-5-phenyl-2-thioxo-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-one
• CAS No.: 445220-54-2
• Molecular Formula: C18H11ClN2OS2
• Molecular Weight: 370.87600
• Mol file: 445220-54-2.mol

Synonyms:3-(4-Chloro-phenyl)-2-mercapto-5-phenyl-3H-thieno[2,3-d]pyrimidin-4-one;

Chemical Property of 3-(4-chlorophenyl)-5-phenyl-2-thioxo-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-one

Chemical Property:

• PSA: 101.93000
• LogP: 5.05630

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-chlorophenyl)-5-phenyl-2-thioxo-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-one

There total 5 articles about 3-(4-chlorophenyl)-5-phenyl-2-thioxo-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[3-(4-chloro-phenyl)-thioureido]-4-phenyl-thiophene-3-carboxylic acid ethyl ester → 3-(4-chlorophenyl)-2-mercapto-5-phenyl-3H-thieno[2,3-d]pyrimidin-4-one (445220-54-2)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃;

DOI:10.1016/j.bmcl.2005.02.005

Reference yield:

ethyl 2-amino-4-phenyl-thiophene-3-carboxylate (4815-36-5) → 3-(4-chlorophenyl)-2-mercapto-5-phenyl-3H-thieno[2,3-d]pyrimidin-4-one (445220-54-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 50 °C

2: MeONa / methanol / 20 °C

With pyridine; sodium methylate; In methanol;

DOI:10.1016/j.bmcl.2005.02.005

Reference yield:

4-Chlorophenyl isothiocyanate (2131-55-7) → 3-(4-chlorophenyl)-2-mercapto-5-phenyl-3H-thieno[2,3-d]pyrimidin-4-one (445220-54-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 50 °C

2: MeONa / methanol / 20 °C

With pyridine; sodium methylate; In methanol;

DOI:10.1016/j.bmcl.2005.02.005

upstream raw materials:

ethyl 2-amino-4-phenyl-thiophene-3-carboxylate

4-Chlorophenyl isothiocyanate

acetophenone

Downstream raw materials:

[3-(4-chloro-phenyl)-4-oxo-5-phenyl-3,4-dihydro-thieno[2,3-d]pyrimidin-2-ylsulfanyl]-acetic acid ethyl ester

2-(2-(3-(4-chlorophenyl)-3,4-dihydro-4-oxo-5-phenylthieno[2,3-d]pyrimidin-2-ylthio)acetamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide