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Base Information Edit
  • Chemical Name:Acetophenone
  • CAS No.:98-86-2
  • Molecular Formula:C8H8O
  • Molecular Weight:120.151
  • Hs Code.:2914.30 Oral rat LD50: 815 mg/kg
  • European Community (EC) Number:202-708-7,687-079-0
  • ICSC Number:1156
  • NSC Number:7635
  • UN Number:1993
  • UNII:RK493WHV10
  • DSSTox Substance ID:DTXSID6021828
  • Nikkaji Number:J3.225E
  • Wikipedia:Acetophenone
  • Wikidata:Q375112
  • NCI Thesaurus Code:C77447
  • RXCUI:2467143
  • Metabolomics Workbench ID:46273
  • ChEMBL ID:CHEMBL274467
  • Mol file:98-86-2.mol


Suppliers and Price of Acetophenone
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
Total 259 raw suppliers
Chemical Property of Acetophenone Edit
Chemical Property:
  • Appearance/Colour:clear to light yellow liquid 
  • Melting Point:19-20 °C(lit.) 
  • Refractive Index:1.5340 
  • Boiling Point:202 °C at 760 mmHg 
  • Flash Point:80.9 °C 
  • PSA:17.07000 
  • Density:0.993 g/cm3 
  • LogP:1.88920 
  • Water Solubility.:5.5 g/L (20℃) 
  • XLogP3:1.6
  • Hydrogen Bond Donor Count:0
  • Hydrogen Bond Acceptor Count:1
  • Rotatable Bond Count:1
  • Exact Mass:120.057514874
  • Heavy Atom Count:9
  • Complexity:101
  • Transport DOT Label:Combustible Liquid

99%, *data from raw suppliers

Safty Information:
  • Pictogram(s): HarmfulXn,ToxicT,Flammable
  • Hazard Codes: Xn:Harmful;
  • Statements: R22:; R36:; 
  • Safety Statements: S26:; 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

  • Chemical Classes:Other Classes -> Aromatic Ketones
  • Canonical SMILES:CC(=O)C1=CC=CC=C1
  • Inhalation Risk:A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20 °C; on spraying or dispersing, however, much faster.
  • Effects of Short Term Exposure:The substance is irritating to the eyes. The substance may cause effects on the central nervous system.
  • Effects of Long Term Exposure:The substance defats the skin, which may cause dryness or cracking.
  • Chemical structure Acetophenone is an aromatic ketone with a phenyl ring attached to a carbonyl group.
  • Uses Acetophenone has been known and used for various purposes since at least the mid-20th century.
    Utilized as a solvent, catalyst, and photosensitizer in various industrial processes.
    Apocynin, a naturally occurring acetophenone found in certain plants, has been extensively studied for its pharmacological effects, including as an inhibitor of NADPH oxidase and for its potential therapeutic applications.[1]
  • Production Methods Acetophenone can be synthesized industrially through various methods, including the oxidation of ethylbenzene and isopropylbenzene. The use of heterogeneous Ti–Zr–Co alloy catalyst for the oxidation of ethylbenzene to acetophenone is a recent development.[2]
  • References [1] Pharmacology of apocynin: a natural acetophenone (DOI 10.1080/03602532.2021.1895203)
    [2] Synthesis of acetophenone from aerobic catalytic oxidation of ethylbenzene over Ti–Zr–Co alloy catalyst: Influence of annealing conditions (DOI 10.1016/j.apcata.2015.12.008)
Technology Process of Acetophenone

There total 4154 articles about Acetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
styrene; With RhCl(PPh3)3; benzo[1,3,2]dioxaborole; In tetrahydrofuran; at 0 - 5 ℃; for 1h;
With oxygen; triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 12h;
Guidance literature:
With N-hydroxyphthalimide; oxygen; butane-2,3-dione dioxime; In acetonitrile; at 80 ℃; for 6h; under 2250.23 Torr;
Guidance literature:
With N,N-dichloro-t-butylamine; at 20 ℃; for 1h; Irradiation;
Refernces Edit
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