Chemical Property of Acetophenone
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Chemical Property:
- Appearance/Colour:clear to light yellow liquid
- Melting Point:19-20 °C(lit.)
- Refractive Index:1.5340
- Boiling Point:202 °C at 760 mmHg
- Flash Point:80.9 °C
- PSA：17.07000
- Density:0.993 g/cm3
- LogP:1.88920
- Water Solubility.:5.5 g/L (20℃)
- XLogP3:1.6
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:1
- Rotatable Bond Count:1
- Exact Mass:120.057514874
- Heavy Atom Count:9
- Complexity:101
- Transport DOT Label:Combustible Liquid
- Purity/Quality:
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99%, *data from raw suppliers
Safty Information:
- Pictogram(s):
Xn,
T,
F
- Hazard Codes:
Xn:Harmful;
- Statements:
R22:;
R36:;
- Safety Statements:
S26:;
- MSDS Files:
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SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Chemical Classes:Other Classes -> Aromatic Ketones
- Canonical SMILES:CC(=O)C1=CC=CC=C1
- Inhalation Risk:A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20 °C; on spraying or dispersing, however, much faster.
- Effects of Short Term Exposure:The substance is irritating to the eyes. The substance may cause effects on the central nervous system.
- Effects of Long Term Exposure:The substance defats the skin, which may cause dryness or cracking.
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Chemical structure
Acetophenone is an aromatic ketone with a phenyl ring attached to a carbonyl group.
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Uses
Acetophenone has been known and used for various purposes since at least the mid-20th century.
Utilized as a solvent, catalyst, and photosensitizer in various industrial processes.
Apocynin, a naturally occurring acetophenone found in certain plants, has been extensively studied for its pharmacological effects, including as an inhibitor of NADPH oxidase and for its potential therapeutic applications.[1]
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Production Methods
Acetophenone can be synthesized industrially through various methods, including the oxidation of ethylbenzene and isopropylbenzene. The use of heterogeneous Ti–Zr–Co alloy catalyst for the oxidation of ethylbenzene to acetophenone is a recent development.[2]
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References
[1] Pharmacology of apocynin: a natural acetophenone (DOI 10.1080/03602532.2021.1895203)
[2] Synthesis of acetophenone from aerobic catalytic oxidation of ethylbenzene over Ti–Zr–Co alloy catalyst: Influence of annealing conditions (DOI 10.1016/j.apcata.2015.12.008)
