1-(chloromethyl)-4-cyclohexylbenzene

Base Information

• Chemical Name: 1-(chloromethyl)-4-cyclohexylbenzene
• CAS No.: 4463-31-4
• Molecular Formula: C13H17Cl
• Molecular Weight: 208.731
• Hs Code.: 2903999090
• Mol file: 4463-31-4.mol

Synonyms:4-cicloesil-;

Chemical Property of 1-(chloromethyl)-4-cyclohexylbenzene

Chemical Property:

• PSA: 0.00000
• LogP: 4.47310

Purity/Quality:

99% ^*data from raw suppliers

1-(chloromethyl)-4-cyclohexylbenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(chloromethyl)-4-cyclohexylbenzene

There total 11 articles about 1-(chloromethyl)-4-cyclohexylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-cyclohexylphenylmethyl alcohol (208259-47-6) → 4-cyclohexylbenzyl chloride (4463-31-4)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 ℃; for 0.5h;

Reference yield: 65.0%

p-bromobenzyl chloride (589-17-3) + cyclohexylzinc chloride (256390-55-3) → 4-cyclohexylbenzyl chloride (4463-31-4)

Guidance literature:

With di-μ-iodobis(tri-t-butylphosphino)dipalladium(l); In tetrahydrofuran; toluene; at 20 ℃; for 0.0833333h; chemoselective reaction;

DOI:10.1002/anie.201701691

Reference yield: 57.0%

1-phenyl-1-cyclohexane (827-52-1,5379-26-0) + chloromethyl methyl ether (107-30-2) → 4-cyclohexylbenzyl chloride (4463-31-4)

Guidance literature:

With tin(IV) chloride; In carbon disulfide; for 1h; Inert atmosphere; Cooling with ice;

DOI:10.1016/j.bmcl.2015.04.038

upstream raw materials:

formaldehyd

1-phenyl-1-cyclohexane

4-cyclohexylphenylmethyl alcohol

chloromethyl methyl ether

Downstream raw materials:

diethyl-(4-cyclohexyl-benzyl)-amine

4-cyclohexylbenzaldehyde

4-cyclohexylbenzoic acid

4-(4-cyclohexylbenzyloxy)benzaldehyde

Refernces

• 1、 Kalvet, Indrek,Sperger, Theresa,Scattolin, Thomas,Magnin, Guillaume,Schoenebeck, Franziska. "Palladium(I) Dimer Enabled Extremely Rapid and Chemoselective Alkylation of Aryl Bromides over Triflates and Chlorides in Air". supporting information. p. 7078 - 7082. Retrieved 2017/06/13.
• 2、 -. "NOVEL PROTEIN TYROSINE PHOSPHATASE - IB INHIBITORS". Page/Page column 47. . Retrieved 2009/10/22.