Methyl 2-hydroxy-4-(2-hydroxyethylamino)benzoate

Base Information

• Chemical Name: Methyl 2-hydroxy-4-(2-hydroxyethylamino)benzoate
• CAS No.: 6950-58-9
• Molecular Formula: C₁₀H₁₃NO₄
• Molecular Weight: 211.218
• NSC Number: 65773
• DSSTox Substance ID: DTXSID80289952
• Wikidata: Q82027502
• Mol file: 6950-58-9.mol

Synonyms:6950-58-9;methyl 2-hydroxy-4-(2-hydroxyethylamino)benzoate;NSC65773;DTXSID80289952;NSC-65773

Chemical Property of Methyl 2-hydroxy-4-(2-hydroxyethylamino)benzoate

Chemical Property:

• Vapor Pressure: 3.42E-07mmHg at 25°C
• Boiling Point: 402.2°Cat760mmHg
• Flash Point: 197.1°C
• Density: 1.326g/cm³
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 211.08445790
• Heavy Atom Count: 15
• Complexity: 210

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C1=C(C=C(C=C1)NCCO)O

Technology Process of Methyl 2-hydroxy-4-(2-hydroxyethylamino)benzoate

There total 2 articles about Methyl 2-hydroxy-4-(2-hydroxyethylamino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

oxirane (75-21-8,99932-75-9) + methyl 4-aminosalicylate (4136-97-4) → 2-hydroxy-4-(2-hydroxy-ethylamino)-benzoic acid methyl ester (6950-58-9)

Guidance literature:

With diethyl ether; boron trifluoride diethyl etherate;

DOI:10.1021/ja01131a063

Reference yield:

→ 2-hydroxy-4-(2-hydroxy-ethylamino)-benzoic acid methyl ester (6950-58-9)

Guidance literature:

4-Amino-salicylsaeure-methylester, Ethylenoxid, Eg.; (neben geringeren Mengen 4--salicylsaeure-methylester);

DOI:10.1021/jo01056a073

Reference yield:

2-hydroxy-4-(2-hydroxy-ethylamino)-benzoic acid methyl ester (6950-58-9) → 2-hydroxy-4-(2-hydroxy-ethylamino)-benzoic acid

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01131a063

upstream raw materials:

oxirane

methyl 4-aminosalicylate

Downstream raw materials:

3-<(4-Carbomethoxy-3-hydroxy)-phenyl>-2-chlor-1.3.2-oxazaphospholidin-2-oxid

4-(2-aziridin-1-yl-2-oxo-2λ⁵-[1,3,2]oxazaphospholidin-3-yl)-2-hydroxy-benzoic acid methyl ester