Ethylene Oxide

Base Information

• Chemical Name: Ethylene Oxide
• CAS No.: 75-21-8
• Deprecated CAS: 184288-32-2,19034-08-3,37341-05-2,99932-75-9,142175-32-4,436859-78-8,142175-32-4,19034-08-3,37341-05-2,436859-78-8,99932-75-9
• Molecular Formula: C2H4O
• Molecular Weight: 44.0532
• Hs Code.: 2910100000
• European Community (EC) Number: 200-849-9
• ICSC Number: 0155
• UN Number: 1040
• UNII: JJH7GNN18P
• DSSTox Substance ID: DTXSID0020600
• Nikkaji Number: J1.942I
• Wikipedia: Ethylene oxide
• Wikidata: Q407473,Q83056503
• NCI Thesaurus Code: C29821
• Metabolomics Workbench ID: 51372
• ChEMBL ID: CHEMBL1743219
• Mol file: 75-21-8.mol

Synonyms:Ethylene Oxide;Oxide, Ethylene;Oxirane

Chemical Property of Ethylene Oxide

Chemical Property:

• Appearance/Colour: clear colorless gas with an ethereal odor
• Vapor Pressure: 1260mmHg at 25°C
• Melting Point: - 111 °C(lit.)
• Refractive Index: n20/D 1.3597(lit.)
• Boiling Point: 10.699 °C at 760 mmHg
• Flash Point: 低于-17.7oC
• PSA: 12.53000
• Density: 0.995 g/cm³
• LogP: 0.01660
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 44.026214747
• Heavy Atom Count: 3
• Complexity: 10.3
• Transport DOT Label: Poison Gas Flammable Gas

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s): F+; T
• Hazard Codes: F+; T

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Pesticides -> Fumigants
• Canonical SMILES: C1CO1
• Recent ClinicalTrials: Protocol for the Treatment of Metastatic Ewing Sarcoma
• Inhalation Risk: A harmful concentration of this gas in the air will be reached very quickly on loss of containment.
• Effects of Short Term Exposure: The vapour is irritating to the eyes, skin and respiratory tract. Water solutions may cause skin blisters. Rapid evaporation of the liquid may cause frostbite.
• Effects of Long Term Exposure: Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. The substance may have effects on the nervous system. This substance is carcinogenic to humans. May cause heritable genetic damage to human germ cells.

Technology Process of Ethylene Oxide

There total 152 articles about Ethylene Oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

hexane (110-54-3) → oxirane (75-21-8,99932-75-9) + 2-ethyltetrahydrofuran (1003-30-1,123931-62-4) + 2-ethyl-4-methyloxetane (5410-21-9) + 2,5-dimethyltetrahydrofuran (1003-38-9) + 2-methyloxane (10141-72-7) + 2,3-diethyloxirane (4468-66-0,36611-93-5,36611-94-6,124718-82-7,135559-58-9,149951-15-5) + 1,2-Epoxyhexane (1436-34-6) + 2,3-epoxyhexane (1192-32-1) + 2-propyl-oxetane (4468-64-8) + methanol (67-56-1) + Ketene (463-51-4) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + propene (187737-37-7,13987-01-4,15220-87-8,9003-07-0,676-63-1,25085-53-4) + methane (34557-54-5,27936-85-2) + ethane (74-84-0) + ethene (74-85-1) + 1,2-propanediene (463-49-0) + acetaldehyde (75-07-0,9002-91-9) + acetic acid (64-19-7,77671-22-8) + propionic acid (802294-64-0,79-09-4) + buta-1,3-diene (106-99-0,130983-70-9,29406-96-0,9003-17-2) + methyloxirane (75-56-9,16033-71-9) + prop-1-yne (74-99-7) + acetylene (74-86-2,25067-58-7)

Guidance literature:

With oxygen; at 376.84 ℃; for 0.000555556h; under 795.08 Torr; Temperature; Inert atmosphere;

DOI:10.1021/jp503772h

Reference yield:

styrene oxide (96-09-3) + 2-diphenylphosphinoethanol (2360-04-5) → oxirane (75-21-8,99932-75-9) + styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + ethene (74-85-1) + acetaldehyde (75-07-0,9002-91-9) + acetophenone (98-86-2)

Guidance literature:

In chlorobenzene; at 150 ℃; for 1h; Mechanism; a new decomposition path of reaction;

DOI:10.1007/BF01157345

Reference yield:

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) → oxirane (75-21-8,99932-75-9) + phenylethane 1,2-diol (93-56-1) + benzaldehyde (100-52-7) + benzalacetophenone (94-41-7)

Guidance literature:

With tert.-butylhydroperoxide; In acetonitrile; at 80 ℃; for 10h; Reagent/catalyst; Temperature; Catalytic behavior;

DOI:10.1016/j.molcata.2016.08.031

upstream raw materials:

[1,3]-dioxolan-2-one

Perbenzoic acid

ethene

1-chloro-2-iodoethane

Downstream raw materials:

2-(1-aziridine)ethanol

homoalylic alcohol

1,1,1-triphenyl-1-silapropan-3-ol

1-pyrrolidineethanol

Refernces

• 1、 Vayenas,Yentekakis,Bebelis,Neophytides. "In situ controlled promotion of catalyst surfaces via solid electrolytes: the NEMCA effect". . p. 1393 - 1401. Retrieved 1995.
• 2、 Ramirez, Adrian,Hueso, Jose L.,Suarez, Hugo,Mallada, Reyes,Ibarra, Alfonso,Irusta, Silvia,Santamaria, Jesus. "A Nanoarchitecture Based on Silver and Copper Oxide with an Exceptional Response in the Chlorine-Promoted Epoxidation of Ethylene". . p. 11158 - 11161. Retrieved 2016.
• 3、 Tsybulya, S. V.,Kryukova, G. N.,Goncharova, S. N.,Shmakov, A. N.,Bal'zhinimaev, B. S.. "Study of the Real Structure of Silver Supported Catalysts of Different Dispersity". . p. 194 - 200. Retrieved 1995.
• 4、 Wu, Ying,Wu, Binfu,He, Yiming,Wu, Tinghua. "Direct conversion of ethane to ethylene oxide over Ni-Ag-O catalyst". . p. 284 - 285. Retrieved 2009.
• 5、 Wu, Yun-Dong,Sun, Jian. "Transition Structures of Epoxidation by CH3Re(O)2(O2) and CH3Re(O)(O2)2 and Their Water Adducts". . p. 1752 - 1753. Retrieved 1998.
• 6、 Swain et al.. "-". . p. 2353,2357,2358. Retrieved 1959.
• 7、 Twigg et al.. "-". . p. 699,704. Retrieved 1952.
• 8、 Ballinger,Long. "-". . p. 2347,2349. Retrieved 1959.
• 9、 -. "PRODUCTION PROCESS OF ALKYLENE OXIDES FROM ALKYLENE CARBONATES". Page/Page column 10-12. . Retrieved 2022/04/03.
• 10、 Arsentev, S. D.,Grigoryan, R. R.. "Epoxidation of Ethylene with Products of Thermal Gas-Phase Oxidation of n-Butane". . p. 187 - 193. Retrieved 2020/03/30.