N-(3-fluoro-4-Methoxyphenyl)acetaMide

Base Information

• Chemical Name: N-(3-fluoro-4-Methoxyphenyl)acetaMide
• CAS No.: 452-15-3
• Molecular Formula: C9H10FNO2
• Molecular Weight: 183.182
• Hs Code.: 2924299090
• Mol file: 452-15-3.mol

Synonyms:3-fluoro-4-methoxybromobenzene;Benzene,4-bromo-2-fluoro-1-methoxy;4-Bromo-2-fluoroanisole;3-fluoro-4-methoxy-acetanilide;4-acetamido-2-fluoroanisole;2-fluoro-4-bromo anisole;4-brom-2-fluor-1-methoxybenzol;4-BROMO-2-FLUOROPHENYLMETHYL ETHER;p-bromo-o-fluoroanisole;1-Bromo-3-fluoro-4-methoxybenzene;3-fluoro-4-methoxy-1-bromobenzene;

Chemical Property of N-(3-fluoro-4-Methoxyphenyl)acetaMide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 112-112.5 °C
• Boiling Point: 341.245oC at 760 mmHg
• PKA: 13.74±0.70(Predicted)
• Flash Point: 160.18oC
• PSA: 41.82000
• Density: 1.215g/cm3
• LogP: 2.44220

Purity/Quality:

98%Min ^*data from raw suppliers

N-(3-Fluoro-4-methoxyphenyl)acetamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(3-fluoro-4-Methoxyphenyl)acetaMide

There total 7 articles about N-(3-fluoro-4-Methoxyphenyl)acetaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-fluoro-4-methoxyaniline (366-99-4) + acetic anhydride (108-24-7) → N-(3-fluoro-4-methoxyphenyl)acetamide (452-15-3)

Guidance literature:

In dichloromethane; at 25 - 30 ℃; for 5h;

Reference yield: 78.0%

1-(3-fluoro-4-methoxy-phenyl)-ethanone oxime → N-(3-fluoro-4-methoxyphenyl)acetamide (452-15-3)

Guidance literature:

With ammonium peroxydisulfate; dimethyl sulfoxide; In 1,4-dioxane; at 100 ℃; for 4h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.6b01634

Reference yield:

3-fluoro-4-methoxyaniline (366-99-4) → N-(3-fluoro-4-methoxyphenyl)acetamide (452-15-3)

Guidance literature:

With acetic anhydride; sodium hydrogencarbonate; triethylamine; In sodium chloride; dichloromethane;

upstream raw materials:

2-fluoro-1-methoxy-4-nitrobenzene

acetic anhydride

3-fluoro-4-methoxyaniline

1-fluoro-2-methoxybenzene

Downstream raw materials:

N-(3-fluoro-4-hydroxy-phenyl)acetamide

2-chloro-7-fluoro-6-methoxy-3-quinolinecarbaldehyde

N-(5-fluoro-4-methoxy-2-nitrophenyl)acetamide

5-fluoro-4-methoxy-2-nitroaniline

Refernces

• 1、 -. "Benzimidazole compound, and preparation method, intermediate and application thereof". Paragraph 0168; 0169; 0170; 0171. . Retrieved 2016/10/20.
• 2、 -. "SUBSTITUTED 6,7-DIALKOXY-3-ISOQUINOLINOL DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE 10 (PDE10A)". Page/Page column 86. . Retrieved 2012/09/05.