2-chloro-7-fluoro-6-methoxy-3-quinolinecarbaldehyde

Base Information

• Chemical Name: 2-chloro-7-fluoro-6-methoxy-3-quinolinecarbaldehyde
• CAS No.: 251902-52-0
• Molecular Formula: C₁₁H₇ClFNO₂
• Molecular Weight: 239.633
• Mol file: 251902-52-0.mol

Synonyms:

Chemical Property of 2-chloro-7-fluoro-6-methoxy-3-quinolinecarbaldehyde

Chemical Property:

• Boiling Point: 383.3±37.0 °C(Predicted)
• Density: 1.421±0.06 g/cm3(Predicted)

Purity/Quality:

95+% ^*data from raw suppliers

2-chloro-7-fluoro-6-methoxyquinoline-3-carbaldehyde 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-7-fluoro-6-methoxy-3-quinolinecarbaldehyde

There total 5 articles about 2-chloro-7-fluoro-6-methoxy-3-quinolinecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

→ 2-chloro-7-fluoro-6-hydoxy-3-quinolinecarbaldehyde + 2-chloro-7-fluoro-6-methoxy-3-quinolinecarbaldehyde (251902-52-0)

Guidance literature:

Reference yield: 18.0%

N-(3-fluoro-4-methoxyphenyl)acetamide (452-15-3) → 2-chloro-7-fluoro-6-methoxy-3-quinolinecarbaldehyde (251902-52-0)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-formamide; at 20 - 160 ℃; microwave irradiation;

Reference yield:

N-(3-fluoro-4-methoxyphenyl)acetamide (452-15-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-chloro-7-fluoro-6-methoxy-3-quinolinecarbaldehyde (251902-52-0)

Guidance literature:

With trichlorophosphate; Multistep reaction; 1.) 0 deg C, 0.5 h, 2.) 70 deg C, 16 h;

DOI:10.1021/jm980400l

upstream raw materials:

N-(3-fluoro-4-methoxyphenyl)acetamide

N,N-dimethyl-formamide

3-fluoro-4-methoxyaniline

Refernces

• 1、 -. "Comptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues". Example 72. . Retrieved 2008/06/13.
• 2、 Lavergne, Olivier,Lesueur-Ginot, Laurence,Rodas, Francesc Pla,Kasprzyk, Philip G.,Pommier, Jacques,Demarquay, Danièle,Prévost, Grégoire,Ulibarri, Gérard,Rolland, Alain,Schiano-Liberatore, Anne-Marie,Harnett, Jeremiah,Pons, Dominique,Camara, José,Bigg, Dennis C. H.. "Homocamptothecins: Synthesis and antitumor activity of novel E-ring- modified camptothecin analogues". . p. 5410 - 5419. Retrieved 2007/10/03.