2-CHLORO-5-FLUOROQUINOLINE

Base Information

• Chemical Name: 2-CHLORO-5-FLUOROQUINOLINE
• CAS No.: 455955-27-8
• Molecular Formula: C9H5ClFN
• Molecular Weight: 181.59400
• Hs Code.: 2933499090
• Mol file: 455955-27-8.mol

Synonyms:CL1043;

Chemical Property of 2-CHLORO-5-FLUOROQUINOLINE

Chemical Property:

• Boiling Point: 271.3±20.0 °C(Predicted)
• PKA: -0.66±0.50(Predicted)
• PSA: 12.89000
• Density: 1.366±0.06 g/cm3(Predicted)
• LogP: 3.02730
• Storage Temp.: 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

2-Chloro-5-fluoroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-5-FLUOROQUINOLINE

There total 5 articles about 2-CHLORO-5-FLUOROQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Chloroquinoline (612-62-4) → 2-chloro-5-fluoroquinoline (455955-27-8) + 2-chloro-8-fluoroquinoline (124467-23-8) + 2-chloro-6-fluoro-quinoline (77119-53-0) + 2-chloro-5,8-difluoroquinoline

Guidance literature:

With Flutec^TM PP₁₁; sulfuric acid; fluorine; at 0 - 5 ℃; Title compound not separated from byproducts;

DOI:10.1016/j.jfluchem.2003.11.012

Reference yield:

(E)-N-(3-fluorophenyl)-3-ethoxypropenamide → 2-chloro-5-fluoroquinoline (455955-27-8) + 2-chloro-7-fluoroquinoline

Guidance literature:

(E)-N-(3-fluorophenyl)-3-ethoxypropenamide; With sulfuric acid;

With trichlorophosphate; Further stages.;

DOI:10.1021/jm0200097

Reference yield:

5-Fluor-chinolin-N-oxid (2338-73-0) → 2-chloro-5-fluoroquinoline (455955-27-8)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 1h;

DOI:10.1016/S0968-0896(02)00098-6

upstream raw materials:

5-Fluor-chinolin-N-oxid

2-Chloroquinoline

5-Aminoquinoline

5-fluoroquinoline

Downstream raw materials:

5-fluoro-2-phenylquinoline

Refernces

• 1、 Hazeldine, Stuart T.,Polin, Lisa,Kushner, Juiwanna,White, Kathryn,Bouregeois, Nicole M.,Crantz, Brianna,Palomino, Eduardo,Corbett, Thomas H.,Horwitz, Jerome P.. "II. Synthesis and biological evaluation of some bioisosteres and congeners of the antitumor agent, 2-{4-[(7-chloro-2-quinoxalinyl)oxylphenoxy}propionic acid (XK469)". . p. 3130 - 3137. Retrieved 2007/10/03.