77119-53-0

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-6-fluoroquinoline is used as a key intermediate in the synthesis of various drugs and biologically active compounds. Its unique chemical structure allows for the development of new pharmaceuticals with improved efficacy and reduced side effects.
Used in Agrochemical Industry:
In the agrochemical industry, 2-chloro-6-fluoroquinoline is utilized as a building block for the production of various agrochemicals, such as pesticides and herbicides. Its potential anti-bacterial and anti-inflammatory properties can contribute to the development of more effective and environmentally friendly agricultural products.
Used in Organic Synthesis:
2-Chloro-6-fluoroquinoline is employed as a versatile starting material in organic synthesis, enabling the creation of a wide range of chemical compounds with diverse applications. Its reactivity and functional groups make it a valuable component in the synthesis of complex organic molecules.
Used in Antibacterial Applications:
2-Chloro-6-fluoroquinoline has been studied for its potential anti-bacterial activities, making it a candidate for the development of new antibiotics to combat drug-resistant bacterial infections.
Used in Anti-inflammatory Applications:
Due to its potential anti-inflammatory properties, 2-chloro-6-fluoroquinoline can be used in the development of new anti-inflammatory drugs, providing alternative treatment options for various inflammatory conditions.
Used in Anti-malarial Applications:
2-Chloro-6-fluoroquinoline has shown promise in anti-malarial research, and its potential use in the development of new anti-malarial drugs could contribute to the global fight against malaria.

Upstream product

• 2338-74-1 6-fluoroquinoline N--oxide 
• 98-88-4 benzoyl chloride 
• 22614-75-1 6-fluoro-1H-quinolin-2-one 
• 19358-27-1 N-(4-fluorophenyl)-3-phenylacrylamide 
• 371-40-4 4-fluoroaniline 
• 791626-56-7 (2E)-N-(4-fluorophenyl)-3-phenylacrylamide 
• 612-62-4 2-Chloroquinoline 

Downstream Products

• 791626-57-8 6-fluoroquinolin-2-amine 
• 1224583-32-7 2-(3-methylphenyl)-6-(1H-pyrrole-1-yl)quinoline 

Relevant academic research and scientific papers

Compound as potassium channel modulator

The invention relates to a compound as a potassium channel modulator, which is a compound of a formula (I) or a pharmaceutically acceptable salt thereof. The compound or the pharmaceutically acceptable salt thereof is effective for curing and preventing diseases and symptoms influenced by the activity of potassium ion channels.

A practical and mild chlorination of fused heterocyclic N-oxides

Fused azine N-oxides were selectively chlorinated at C2 in moderate to excellent yields, employing Vilsmeier reagent as both the activating agent and the nucleophilic chloride source. Remarkable features of the method include simple operation, mild reaction conditions, a wide substrate scope, and the use of only stoichiometric amount of POCl3. The potential extension of this method to a one-pot oxidation/chlorination sequence that obviates the need for isolation of the N-oxide intermediates is also validated.

ANTHELMINTIC COMPOUNDS AND COMPOSITIONS AND METHOD OF USING THEREOF

The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X2, X3, X4, X5, X6, X7 and X8 are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.

NITROGEN HETEROCYCLIC COMPOUNDS USEFUL AS PDE10 INHIBITORS

Unsaturated nitrogen heterocyclic compounds of formula (I): (I), as defined in the specification, compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, Huntington's Disease, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

Identification and specificity studies of small-molecule ligands for SH3 protein domains

The Src Homology 3 (SH3) domains are small protein-protein interaction domains that bind proline-rich sequences and mediate a wide range of cell-signaling and other important biological processes. Since deregulated signaling pathways form the basis of many human diseases, the SH3 domains have been attractive targets for novel therapeutics. High-affinity ligands for SH3 domains have been designed; however, these have all been peptide-based and no examples of entirely nonpeptide SH3 ligands have previously been reported. Using the mouse Tec Kinase SH3 domain as a model system for structure-based ligand design, we have identified several simple heterocyclic compounds that selectively bind to the Tec SH3 domain. Using a combination of nuclear magnetic resonance chemical shift perturbation, structure-activity relationships, and site-directed mutagenesis, the binding of these compounds at the proline-rich peptide-binding site has been characterized. The most potent of these, 2-aminoquinoline, bound with Kd = 125 μM and was able to compete for binding with a proline-rich peptide. Synthesis of 6-substitued-2- aminoquinolines resulted in ligands with up to 6-fold improved affinity over 2-aminoquinoline and enhanced specificity for the Tec SH3 domain. Therefore, 2-aminoquinolines may potentially be useful for the development of high affinity small molecule ligands for SH3 domains.

Elemental fluorine Part 15. Selective direct fluorination of quinoline derivatives

Direct fluorination of various quinoline derivatives in acidic reaction media gives fluorinated quinoline products arising from electrophilic substitution processes.

ANTIDEPRESSANT ARYLPIPERAZINE DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS

Compounds of the formula I: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive-compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

Quinolinyloxyphenoxy and quinolyinylthiophenoxy alkanoic acids and derivatives thereof and methods of herbicidal use

Novel 2-quinolinyloxyphenoxy and 2-quinolinylthiophenoxy alkanoic acids, amides, salts, and esters thereof, and nitriles derived therefrom and 2-quinolinyloxy- and thio-phenoxy propanols and esters and ethers thereof having the following formula STR1 wher