[4-(2-AMINO-ETHYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: [4-(2-AMINO-ETHYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER
• CAS No.: 457631-44-6
• Molecular Formula: C13H20N2O2
• Molecular Weight: 236.314
• Mol file: 457631-44-6.mol

Synonyms:(4-(2-AMINO-ETHYL)-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER;tert-butyl (4-(2-aminoethyl)phenyl)carbamate;

Chemical Property of [4-(2-AMINO-ETHYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER

Chemical Property:

• PSA: 64.35000
• LogP: 3.30810

Purity/Quality:

97% ^*data from raw suppliers

[4-(2-Amino-ethyl)-phenyl]-carbamicacidtert-butylester 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [4-(2-AMINO-ETHYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER

There total 15 articles about [4-(2-AMINO-ETHYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4-tert-butoxycarbonylaminophenylacetonitrile (1233249-35-8) → 4-(2-aminoethyl)-N-(tert-butoxycarbonyl)phenylamine (457631-44-6)

Guidance literature:

With ammonia; hydrogen; In methanol; water; at 25 - 30 ℃; for 4h; under 2585.81 - 3102.97 Torr; Reagent/catalyst;

Reference yield: 78.0%

p-Aminophenethylamine (13472-00-9) + di-tert-butyl dicarbonate (24424-99-5) → 4-(2-aminoethyl)-N-(tert-butoxycarbonyl)phenylamine (457631-44-6)

Guidance literature:

at 20 ℃; regioselective reaction;

DOI:10.1021/jo401778e

Reference yield: 69.0%

tert-butyl (4-(2-propionamidoethyl)phenyl)carbamate → 4-(2-aminoethyl)-N-(tert-butoxycarbonyl)phenylamine (457631-44-6)

Guidance literature:

With hydroxylamine trifluoroacetate; In tetrahydrofuran; at 80 ℃; pH=7; chemoselective reaction; Sealed tube;

DOI:10.1002/ejoc.201800304

upstream raw materials:

p-Aminophenethylamine

di-tert-butyl dicarbonate

4-tert-butoxycarbonylaminophenylacetonitrile

4-Nitrophenylacetonitrile

Downstream raw materials:

{4-[2-(2-[1,2]dithiolan-3-yl-acetylamino)-ethyl]-phenyl}-carbamic acid tert-butyl ester

{4-[2-(5-[1,2]dithiolan-3-yl-pentanoylamino)-ethyl]-phenyl}-carbamic acid tert-butyl ester

N-[2-(4-amino-phenyl)-ethyl]-2-[1,2]dithiolan-3-yl-acetamide

5-[1,2]dithiolan-3-yl-pentanoic acid [2-(4-amino-phenyl)ethyl]amide

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