1(2H)-Pyridinecarboxylic acid, 4-(4-cyanophenyl)-3,6-dihydro-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1(2H)-Pyridinecarboxylic acid, 4-(4-cyanophenyl)-3,6-dihydro-, 1,1-dimethylethyl ester
CAS No.:460365-08-6
Molecular Formula:C17H20N2O2
Molecular Weight:284.358
Hs Code.:
Mol file:460365-08-6.mol

Synonyms:4-(4-Cyano-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester;tert-butyl 4-(4-cyanophenyl)-5,6-dihydropyridine-1(2H)-carboxylate;1-tert-butyloxycarbonyl-4-(4-cyanophenyl)-1,2,3,6-tetrahydropyridine;tert-butyl 4-(4-cyanophenyl)-3,6-dihydropyridine-1(2H)-carboxylate;

Suppliers and Price of 1(2H)-Pyridinecarboxylic acid, 4-(4-cyanophenyl)-3,6-dihydro-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 1(2H)-Pyridinecarboxylic acid, 4-(4-cyanophenyl)-3,6-dihydro-, 1,1-dimethylethyl ester

Chemical Property:

PSA：53.33000
LogP:3.52038

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1(2H)-Pyridinecarboxylic acid, 4-(4-cyanophenyl)-3,6-dihydro-, 1,1-dimethylethyl ester

There total 12 articles about 1(2H)-Pyridinecarboxylic acid, 4-(4-cyanophenyl)-3,6-dihydro-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.8%

: 623-00-7
4-bromobenzenecarbonitrile

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 460365-08-6
4-(4-cyanophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dichloromethane; at 110 ℃; for 24h; Inert atmosphere;

Reference yield: 74.0%

: 871112-38-8
tert-butyl 4-(4-cyanophenyl)-4-hydroxypiperidine-1-carboxylate

: 460365-08-6
4-(4-cyanophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Guidance literature:: With trichlorophosphate; In pyridine; at 20 ℃; Inert atmosphere;
DOI:10.1021/ml300335r

Reference yield: 29.0%

: 856684-31-6
tert-butyl 4-((diphenoxyphosphoryl)oxy)-3,6-dihydropyridine-1(2H)-carboxylate

: 126747-14-6
4-cyanophenylboronic acid

: 460365-08-6
4-(4-cyanophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Guidance literature:: With potassium fluoride; johnphos; palladium diacetate; In 1,2-dimethoxyethane; water; at 150 ℃; for 0.0833333h; microwave irradiation;
DOI:10.1016/j.tetlet.2005.03.203