6-(3,3-diphenylpropyl)guvacine

Base Information

Chemical Name:6-(3,3-diphenylpropyl)guvacine
CAS No.:134420-91-0
Molecular Formula:C21H23 N O2 . Cl H
Molecular Weight:357.87376
Hs Code.:
Mol file:134420-91-0.mol

Synonyms:3-Pyridinecarboxylicacid, 6-(3,3-diphenylpropyl)-1,2,5,6-tetrahydro-, hydrochloride (9CI)

Suppliers and Price of 6-(3,3-diphenylpropyl)guvacine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 6-(3,3-diphenylpropyl)guvacine

Chemical Property:

Vapor Pressure:9.53E-11mmHg at 25°C
Boiling Point:498.3°Cat760mmHg
Flash Point:255.1°C
PSA：49.33000
Density:g/cm³
LogP:5.10240

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-(3,3-diphenylpropyl)guvacine

There total 10 articles about 6-(3,3-diphenylpropyl)guvacine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 134420-88-5
2-(3,3-diphenylpropyl)-5-carbethoxy-1,2,3,6-tetrahydropyridine hydrochloride

: 134420-91-0
6-(3,3-diphenylpropyl)guvacine hydrochloride

Guidance literature:: With hydrogenchloride; for 3h; Heating;
DOI:10.1021/jm00112a032

Reference yield:

: 134420-92-1
ethyl 6,6-diphenyl-2-hexenoate

: 134420-91-0
6-(3,3-diphenylpropyl)guvacine hydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1: 62 percent / ethanol / 48 h / Heating

2: 95 percent / H₂ / 5percent Pd/C / ethanol / 3 h / 3040 Torr

3: 95 percent / ethanol / Ambient temperature

4: 95 percent / 5percent aq. potassium carbonate / dioxane / a) 0 deg C, 15 min, b) RT, 3 h

5: 87 percent / sodium / ethanol; benzene / 24 h / Ambient temperature

6: H₂ / 20percent Raney nickel / ethanol / 80 °C / 45600 Torr

7: Heating

8: 90 percent / 1,5-diazabicyclo<4.3.0>non-5-ene / tetrahydrofuran / 3 h / Ambient temperature

9: 58 percent / sat. ethanolic HCl / 2 h / Heating

10: 70 percent / 3 N aq. HCl / 3 h / Heating

With hydrogenchloride; DBN; hydrogen; sodium; potassium carbonate; palladium on activated charcoal; nickel; In tetrahydrofuran; 1,4-dioxane; ethanol; benzene;
DOI:10.1021/jm00112a032

Reference yield:

: 134420-71-6
ethyl 3-amino-6,6-diphenylcaproate

: 134420-91-0
6-(3,3-diphenylpropyl)guvacine hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: 95 percent / ethanol / Ambient temperature

2: 95 percent / 5percent aq. potassium carbonate / dioxane / a) 0 deg C, 15 min, b) RT, 3 h

3: 87 percent / sodium / ethanol; benzene / 24 h / Ambient temperature

4: H₂ / 20percent Raney nickel / ethanol / 80 °C / 45600 Torr

5: Heating

6: 90 percent / 1,5-diazabicyclo<4.3.0>non-5-ene / tetrahydrofuran / 3 h / Ambient temperature

7: 58 percent / sat. ethanolic HCl / 2 h / Heating

8: 70 percent / 3 N aq. HCl / 3 h / Heating

With hydrogenchloride; DBN; hydrogen; sodium; potassium carbonate; nickel; In tetrahydrofuran; 1,4-dioxane; ethanol; benzene;
DOI:10.1021/jm00112a032