2-(3,3-diphenylpropyl)-5-carbethoxy-1,2,3,6-tetrahydropyridine hydrochloride

Base Information

Chemical Name:2-(3,3-diphenylpropyl)-5-carbethoxy-1,2,3,6-tetrahydropyridine hydrochloride
CAS No.:134420-88-5
Molecular Formula:C₂₃H₂₇NO₂*ClH
Molecular Weight:385.934
Hs Code.:

Synonyms:2-(3,3-diphenylpropyl)-5-carbethoxy-1,2,3,6-tetrahydropyridine hydrochloride

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Chemical Property of 2-(3,3-diphenylpropyl)-5-carbethoxy-1,2,3,6-tetrahydropyridine hydrochloride

Chemical Property:

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Technology Process of 2-(3,3-diphenylpropyl)-5-carbethoxy-1,2,3,6-tetrahydropyridine hydrochloride

There total 9 articles about 2-(3,3-diphenylpropyl)-5-carbethoxy-1,2,3,6-tetrahydropyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 134420-86-3
N-(tert-butyloxycarbonyl)-2-(3,3-diphenylpropyl)-5-carbethoxy-1,2,3,6-tetrahydropyridine

: 134420-88-5
2-(3,3-diphenylpropyl)-5-carbethoxy-1,2,3,6-tetrahydropyridine hydrochloride

Guidance literature:: With hydrogenchloride; for 2h; Heating;
DOI:10.1021/jm00112a032

Reference yield:

: 134420-92-1
ethyl 6,6-diphenyl-2-hexenoate

: 134420-88-5
2-(3,3-diphenylpropyl)-5-carbethoxy-1,2,3,6-tetrahydropyridine hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: 62 percent / ethanol / 48 h / Heating

2: 95 percent / H₂ / 5percent Pd/C / ethanol / 3 h / 3040 Torr

3: 95 percent / ethanol / Ambient temperature

4: 95 percent / 5percent aq. potassium carbonate / dioxane / a) 0 deg C, 15 min, b) RT, 3 h

5: 87 percent / sodium / ethanol; benzene / 24 h / Ambient temperature

6: H₂ / 20percent Raney nickel / ethanol / 80 °C / 45600 Torr

7: Heating

8: 90 percent / 1,5-diazabicyclo<4.3.0>non-5-ene / tetrahydrofuran / 3 h / Ambient temperature

9: 58 percent / sat. ethanolic HCl / 2 h / Heating

With hydrogenchloride; DBN; hydrogen; sodium; potassium carbonate; palladium on activated charcoal; nickel; In tetrahydrofuran; 1,4-dioxane; ethanol; benzene;
DOI:10.1021/jm00112a032

Reference yield:

: 134420-71-6
ethyl 3-amino-6,6-diphenylcaproate

: 134420-88-5
2-(3,3-diphenylpropyl)-5-carbethoxy-1,2,3,6-tetrahydropyridine hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / ethanol / Ambient temperature

2: 95 percent / 5percent aq. potassium carbonate / dioxane / a) 0 deg C, 15 min, b) RT, 3 h

3: 87 percent / sodium / ethanol; benzene / 24 h / Ambient temperature

4: H₂ / 20percent Raney nickel / ethanol / 80 °C / 45600 Torr

5: Heating

6: 90 percent / 1,5-diazabicyclo<4.3.0>non-5-ene / tetrahydrofuran / 3 h / Ambient temperature

7: 58 percent / sat. ethanolic HCl / 2 h / Heating

With hydrogenchloride; DBN; hydrogen; sodium; potassium carbonate; nickel; In tetrahydrofuran; 1,4-dioxane; ethanol; benzene;
DOI:10.1021/jm00112a032