2-(HydroxyMethyl)-2-phenylpropane-1,3-diol

Base Information

• Chemical Name: 2-(HydroxyMethyl)-2-phenylpropane-1,3-diol
• CAS No.: 4704-99-8
• Molecular Formula: C10H14O3
• Molecular Weight: 182.219
• Hs Code.: 2906299090
• Mol file: 4704-99-8.mol

Synonyms:2-(hydroxymethyl)-2-phenylpropane-1,3-diol;

Chemical Property of 2-(HydroxyMethyl)-2-phenylpropane-1,3-diol

Chemical Property:

• Melting Point: 81-82℃
• PSA: 60.69000
• Density: 1.225
• LogP: -0.09870
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

α,α,α-Tris(hydroxymethyl)toluene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: α,α,α-Tris(hydroxymethyl)toluene (cas# 4704-99-8) is a compound useful in organic synthesis.

Technology Process of 2-(HydroxyMethyl)-2-phenylpropane-1,3-diol

There total 5 articles about 2-(HydroxyMethyl)-2-phenylpropane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2-Benzyloxymethyl-2-phenyl-propane-1,3-diol (160820-67-7) → α,α,α-tris(hydroxymethyl)toluene (4704-99-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 2h; Ambient temperature;

Reference yield: 58.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + phenylacetaldehyde (122-78-1) → α,α,α-tris(hydroxymethyl)toluene (4704-99-8)

Guidance literature:

With calcium hydroxide; In tetrahydrofuran; at 60 - 65 ℃; for 96h;

Reference yield: 43.0%

→ α,α,α-tris(hydroxymethyl)toluene (4704-99-8)

Guidance literature:

upstream raw materials:

formaldehyd

phenylacetaldehyde

2-Benzyloxymethyl-2-phenyl-propane-1,3-diol

2-Benzyloxymethyl-2-phenyl-malonic acid diethyl ester

Downstream raw materials:

4-phenyl-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane

4-Phenyl-2,6,7-trioxa-1-phosphabicyclo<2.2.2>octane 1-oxide

4-Phenyl-2,6,7-trioxa-1-phosphabicyclo<2.2.2>octan-1-sulfid

C₁₉H₂₀O₅

Refernces

• 1、 -. "Single-Side Modified Beta-Anderson-Type Heteropolymolybdate Organic Derivatives". Paragraph 0047; 0048. . Retrieved 2019/12/02.
• 2、 -. "Multypodal tethers for high-density attachment of redox-active moieties to substrates". . . Retrieved 2008/06/13.