Benzenepropanoic acid, b-amino-, hydrochloride

Base Information

• Chemical Name: Benzenepropanoic acid, b-amino-, hydrochloride
• CAS No.: 471259-71-9
• Molecular Formula: C9H11NO2.ClH
• Molecular Weight: 201.653
• Mol file: 471259-71-9.mol

Synonyms:3-Amino-3-phenyl-propionsaeure, Hydrochlorid;3-amino-3-phenylpropanoic acid hydrochloride;(+)-3-amino-3-phenylpropanoic acid hydrochloride;3-amino-3-phenyl-propionic acid , hydrochloride;

Chemical Property of Benzenepropanoic acid, b-amino-, hydrochloride

Chemical Property:

• PSA: 63.32000
• LogP: 2.66340

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenepropanoic acid, b-amino-, hydrochloride

There total 8 articles about Benzenepropanoic acid, b-amino-, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(RS)-2-phenyl-2,3-dihydro-1H-pyridin-4-one (126378-84-5) → (RS)-3-amino-3-phenyl-propionic acid hydrochloride (471259-71-9)

Guidance literature:

(RS)-2-phenyl-2,3-dihydro-1H-pyridin-4-one; With sodium periodate; In tetrahydrofuran; water; at 20 ℃; for 2h;

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 24h;

DOI:10.1021/ol0485518

Reference yield: 92.0%

diethyl 2-(1-(N-tert-butoxycarbonylamino)-1-phenylmethyl)malonate (864871-38-5) → (RS)-3-amino-3-phenyl-propionic acid hydrochloride (471259-71-9)

Guidance literature:

With hydrogenchloride; In water; for 1h; Heating;

DOI:10.1016/j.tet.2005.04.077

Reference yield: 67.0%

(R/S)-3-(acetylamino)-3-phenylpropanoic acid (40638-98-0,583050-93-5) → (RS)-3-amino-3-phenyl-propionic acid hydrochloride (471259-71-9)

Guidance literature:

With hydrogenchloride; for 13h; Heating;

DOI:10.1016/S0040-4039(02)01239-X

upstream raw materials:

(R/S)-3-(acetylamino)-3-phenylpropanoic acid

(RS)-2-phenyl-2,3-dihydro-1H-pyridin-4-one

diethyl 2-(1-(N-tert-butoxycarbonylamino)-1-phenylmethyl)malonate

tris(p-methoxyphenyl)phosphite

Downstream raw materials:

ethyl 3-amino-3-phenylpropanoate hydrochloride

3-acryloylamino-3-phenyl-propionic acid

2-[2-(3-acryloylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid methyl ester

N-(2-{1-[1-(3-bromo-benzylcarbamoyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-1-phenyl-ethyl)-acrylamide