4-(2-(5-Ethylpyridin-2-yl)-2-hydroxyethoxy)benzaldehyde

Base Information

• Chemical Name: 4-(2-(5-Ethylpyridin-2-yl)-2-hydroxyethoxy)benzaldehyde
• CAS No.: 471295-98-4
• Molecular Formula: C16H17NO3
• Molecular Weight: 271.316
• DSSTox Substance ID: DTXSID501203109
• Mol file: 471295-98-4.mol

Synonyms:471295-98-4;4-(2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy)benzaldehyde;4-[2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy]benzaldehyde;Benzaldehyde, 4-[2-(5-ethyl-2-pyridinyl)-2-hydroxyethoxy]-;SCHEMBL867627;PLYJFAOAGHARMX-UHFFFAOYSA-N;DTXSID501203109;4-[2-(5-Ethyl-2-pyridinyl)-2-hydroxyethoxy]benzaldehyde;4-[2-(5-Ethyl-pyridin-2-yl)-2-hydroxy-ethoxy]-benzaldehyde;4-[2-(5-ethyl-pyridin-2-yl)-2-hydroxy-ethoxy]benzaldehyde;4-[2-(5Ethyl-pyridin-2-yl)-2-hydroxy-ethoxy]-benzaldehyde;4[2-(5-Ethyl-pyridin-2-yl)-2-hydroxy-ethoxy]-benzaldehyde

Chemical Property of 4-(2-(5-Ethylpyridin-2-yl)-2-hydroxyethoxy)benzaldehyde

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 271.12084340
• Heavy Atom Count: 20
• Complexity: 289

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=CN=C(C=C1)C(COC2=CC=C(C=C2)C=O)O

Technology Process of 4-(2-(5-Ethylpyridin-2-yl)-2-hydroxyethoxy)benzaldehyde

There total 23 articles about 4-(2-(5-Ethylpyridin-2-yl)-2-hydroxyethoxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

5-ethyl-2-vinyl-pyridine (5408-74-2) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-[2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy]benzaldehyde (471295-98-4)

Guidance literature:

5-ethyl-2-vinyl-pyridine; With N-Bromosuccinimide; In water; tert-butyl alcohol; at 25 ℃; for 1.5h; Large scale;

With sodium hydroxide; In water; tert-butyl alcohol; for 0.75h; Large scale;

4-hydroxy-benzaldehyde; With sodium hydroxide; In water; toluene; at 78 ℃; for 17h; Reagent/catalyst; Solvent; Temperature; Time; Large scale;

Reference yield: 84.0%

5-ethyl-2-vinyl-pyridine (5408-74-2) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-[2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy]benzaldehyde (471295-98-4) + 4-[1-(5-ethyl-pyridin-2-yl)-2-hydroxy-ethoxy]-benzaldehyde (471296-00-1)

Guidance literature:

5-ethyl-2-vinyl-pyridine; With N-Bromosuccinimide; water; In tert-butyl alcohol; at 25 - 30 ℃; for 1.5h; Industry scale;

With sodium hydroxide; In water; tert-butyl alcohol; for 0.75h; Industry scale;

4-hydroxy-benzaldehyde; With PEG 4000; sodium hydroxide; In water; toluene; at 78 ℃; for 17h; Product distribution / selectivity;

Reference yield: 79.0%

5-ethyl-2-vinyl-pyridine (5408-74-2) + 4-hydroxybenzaldehyde potassium salt (58765-11-0) → 4-[2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy]benzaldehyde (471295-98-4)

Guidance literature:

5-ethyl-2-vinyl-pyridine; With N-Bromosuccinimide; water; In tert-butyl alcohol; at 25 - 30 ℃; for 2.5h;

4-hydroxybenzaldehyde potassium salt; In tert-butyl alcohol; at 75 - 80 ℃; for 18h;

upstream raw materials:

5-ethyl-2-[2-oxo-(1,3,2)dioxathiolan-4-yl]pyridine

4-hydroxy-benzaldehyde

2-bromo-1-(5-ethylpyridin-2-yl)ethanol

5-ethyl-2-vinyl-pyridine

Downstream raw materials:

5-(4-hydroxybenzyl)-2,4-thiazolidinedione

Pioglitazone

5-{4-[2-(5-ethylpyridin-2-yl)-2-mesylethoxy]benzylidene}-2,4-thiazolidene dione

5-{4-[2-(5-ethylpyridin-2-yl)-2-tosylethoxy]benzylidene}-2,4-thiazolidene dione