Pyridine, 5-ethyl-2-(2-oxido-1,3,2-dioxathiolan-4-yl)- (9CI)

Base Information

• Chemical Name: Pyridine, 5-ethyl-2-(2-oxido-1,3,2-dioxathiolan-4-yl)- (9CI)
• CAS No.: 646519-82-6
• Molecular Formula: C₉H₁₁NO₃S
• Molecular Weight: 213.257
• Mol file: 646519-82-6.mol

Synonyms:Pyridine, 5-ethyl-2-(2-oxido-1,3,2-dioxathiolan-4-yl)- (9CI)

Chemical Property of Pyridine, 5-ethyl-2-(2-oxido-1,3,2-dioxathiolan-4-yl)- (9CI)

Chemical Property:

• PSA: 67.63000
• LogP: 2.17630

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyridine, 5-ethyl-2-(2-oxido-1,3,2-dioxathiolan-4-yl)- (9CI)

There total 3 articles about Pyridine, 5-ethyl-2-(2-oxido-1,3,2-dioxathiolan-4-yl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(5-ethylpyridin-2-yl)ethan-1,2-diol → 5-ethyl-2-[2-oxo-(1,3,2)dioxathiolan-4-yl]pyridine (646519-82-6)

Guidance literature:

With thionyl chloride; triethylamine; In dichloromethane; for 1h; Product distribution / selectivity;

Reference yield:

5-ethyl-2-(2-hydroxyethyl)pyridine (5223-06-3) → 5-ethyl-2-[2-oxo-(1,3,2)dioxathiolan-4-yl]pyridine (646519-82-6)

Guidance literature:

Multi-step reaction with 4 steps

1: dihydrogen peroxide / acetic acid / 14 h / 100 °C

2: 0.5 h / 120 °C

3: sodium hydroxide / water / 2 h / 40 °C

4: thionyl chloride; triethylamine / dichloromethane / 1.25 h / 0 - 5 °C

With thionyl chloride; dihydrogen peroxide; triethylamine; sodium hydroxide; In dichloromethane; water; acetic acid;

Reference yield:

acetic acid 2-acetoxy-2-(5-ethyl-1-pyridin-2-yl)ethyl ester → 5-ethyl-2-[2-oxo-(1,3,2)dioxathiolan-4-yl]pyridine (646519-82-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 0.5 h / 120 °C

2: sodium hydroxide / water / 2 h / 40 °C

3: thionyl chloride; triethylamine / dichloromethane / 1.25 h / 0 - 5 °C

With thionyl chloride; triethylamine; sodium hydroxide; In dichloromethane; water;

upstream raw materials:

5-ethyl-2-(2-hydroxyethyl)pyridine

Downstream raw materials:

4-[2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy]benzaldehyde