N-[3-(trifluoromethyl)phenyl]quinazolin-4-amine

Base Information

Chemical Name:N-[3-(trifluoromethyl)phenyl]quinazolin-4-amine
CAS No.:47155-57-7
Molecular Formula:C15H10F3N3
Molecular Weight:289.26
Hs Code.:
DSSTox Substance ID:DTXSID901015643
Nikkaji Number:J715.824F
Wikidata:Q27181442
Pharos Ligand ID:ZFXUSWMA5R5C
ChEMBL ID:CHEMBL92824

Synonyms:N-[3-(trifluoromethyl)phenyl]quinazolin-4-amine;N-[3-(trifluoromethyl)phenyl]-4-quinazolinamine;CHEMBL92824;47155-57-7;BDBM3266;4-Anilino quinazoline deriv. 17;CHEBI:104126;VCOMYMMMFREKQC-UHFFFAOYSA-N;DTXSID901015643;HMS1610A16;STK965440;AKOS000536947;EN300-26866809;Q27181442;N-(4-QUINAZOLINYL)-N-[3-(TRIFLUOROMETHYL)PHENYL]AMINE

Suppliers and Price of N-[3-(trifluoromethyl)phenyl]quinazolin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of N-[3-(trifluoromethyl)phenyl]quinazolin-4-amine

Chemical Property:

XLogP3:4.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:289.08268182
Heavy Atom Count:21
Complexity:348

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C(F)(F)F

Technology Process of N-[3-(trifluoromethyl)phenyl]quinazolin-4-amine

There total 4 articles about N-[3-(trifluoromethyl)phenyl]quinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 5190-68-1
4-chloroquinazoline

: 98-16-8
3-trifluoromethylaniline

: 47155-57-7
quinazolin-4-yl-(3-trifluoromethylphenyl)-amine

Guidance literature:: In isopropyl alcohol; Reflux;
DOI:10.1016/j.bmc.2013.10.007

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 47155-57-7
quinazolin-4-yl-(3-trifluoromethylphenyl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 150 °C

2: trichlorophosphate / 9 h / 0 °C / Reflux

3: isopropyl alcohol / Reflux

With trichlorophosphate; In isopropyl alcohol;
DOI:10.1016/j.bmc.2013.10.007

Reference yield:

: 1885-29-6
anthranilic acid nitrile

: 47155-57-7
quinazolin-4-yl-(3-trifluoromethylphenyl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / 0.08 h / 100 °C / Microwave irradiation

2: diethylamine; trichlorophosphate / 0.17 h / 100 °C / Microwave irradiation

3: 0.25 h / 150 °C / Microwave irradiation; Neat (no solvent)

With sulfuric acid; diethylamine; trichlorophosphate;
DOI:10.1016/j.bmc.2010.11.059