1-(4-Amino-6-bromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride

Base Information

Chemical Name:1-(4-Amino-6-bromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride
CAS No.:111218-73-6
Molecular Formula:C17H16 Br N5 O2 . Cl H
Molecular Weight:0
Hs Code.:
DSSTox Substance ID:DTXSID00149544
ChEMBL ID:CHEMBL1563700
Mol file:111218-73-6.mol

Synonyms:111218-73-6;1-(4-Amino-6-bromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride;Piperazine, 1-(4-amino-6-bromo-2-quinazolinyl)-4-(2-furanylcarbonyl)-, monohydrochloride;[4-(4-amino-6-bromoquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone;hydrochloride;1-(4-Amino-6-bromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hyd rochloride;6-bromo-2-[4-(2-furoyl)-1-piperazinyl]-4-quinazolinylamine;MLS000548049;C17H16BrN5O2.ClH;CHEMBL1563700;DTXSID00149544;VSQLJZNBSAFAIY-UHFFFAOYSA-N;C17-H16-Br-N5-O2.Cl-H;SMR000114482;LS-110214

Suppliers and Price of 1-(4-Amino-6-bromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1-(4-AMINO-6-BROMO-2-QUINAZOLINYL)-4-(2-FURANYLCARBONYL)PIPERAZINE HYDROCHLORIDE 95.00%
5MG
$ 505.45

Total 1 raw suppliers

Chemical Property of 1-(4-Amino-6-bromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride

Chemical Property:

Vapor Pressure:2.22E-16mmHg at 25°C
Boiling Point:642.1°Cat760mmHg
Flash Point:342.1°C
PSA：89.22000
Density:g/cm³
LogP:3.26490
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:437.02542
Heavy Atom Count:26
Complexity:488

Purity/Quality:

99% ^*data from raw suppliers

1-(4-AMINO-6-BROMO-2-QUINAZOLINYL)-4-(2-FURANYLCARBONYL)PIPERAZINE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1C2=NC3=C(C=C(C=C3)Br)C(=N2)N)C(=O)C4=CC=CO4.Cl

Technology Process of 1-(4-Amino-6-bromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride

There total 4 articles about 1-(4-Amino-6-bromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.4%

: 111218-89-4
6-bromo-2-chloroquinazolin-4-amine

: 40172-95-0
N-(furan-2-carbonyl)piperazine

: 111218-73-6
[4-(4-Amino-6-bromo-quinazolin-2-yl)-piperazin-1-yl]-furan-2-yl-methanone; hydrochloride

Guidance literature:: In N,N-dimethyl-formamide; at 95 ℃; for 14h;
DOI:10.1007/BF00758756

Reference yield:

: 88145-89-5
6-bromo-1H-quinazoline-2,4-dione

: 111218-73-6
[4-(4-Amino-6-bromo-quinazolin-2-yl)-piperazin-1-yl]-furan-2-yl-methanone; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 95.2 percent / POCl₃, N,N-dimethylaniline / Heating

2: 74 percent / NH₃(g) / dimethylformamide / 0.67 h / 35 - 40 °C

3: 96.4 percent / dimethylformamide / 14 h / 95 °C

With ammonia; N,N-dimethyl-aniline; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1007/BF00758756

Reference yield:

: 102393-82-8
6-bromo-2,4-dichloroquinazoline

: 111218-73-6
[4-(4-Amino-6-bromo-quinazolin-2-yl)-piperazin-1-yl]-furan-2-yl-methanone; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / NH₃(g) / dimethylformamide / 0.67 h / 35 - 40 °C

2: 96.4 percent / dimethylformamide / 14 h / 95 °C

With ammonia; In N,N-dimethyl-formamide;
DOI:10.1007/BF00758756