9h-Carbazole-1-carboxylic acid

Base Information

• Chemical Name: 9h-Carbazole-1-carboxylic acid
• CAS No.: 6311-19-9
• Molecular Formula: C13H9NO2
• Molecular Weight: 211.22
• NSC Number: 43525
• DSSTox Substance ID: DTXSID30286032
• Wikidata: Q82021615
• Mol file: 6311-19-9.mol

Synonyms:9h-carbazole-1-carboxylic acid;6311-19-9;Carbazole-1-carboxylic acid;SCHEMBL143999;DTXSID30286032;DHHFGQADZVYGIE-UHFFFAOYSA-N;NSC43525;NSC-43525;AKOS000150896

Chemical Property of 9h-Carbazole-1-carboxylic acid

Chemical Property:

• Vapor Pressure: 1.05E-10mmHg at 25°C
• Boiling Point: 497.2°C at 760 mmHg
• Flash Point: 254.5°C
• Density: 1.422g/cm³
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 211.063328530
• Heavy Atom Count: 16
• Complexity: 292

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C3=C(N2)C(=CC=C3)C(=O)O

Technology Process of 9h-Carbazole-1-carboxylic acid

There total 24 articles about 9h-Carbazole-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-iododiphenylamine-2'-carboxylic acid (10166-40-2) → 9H-carbazole-1-carboxylic acid (6311-19-9)

Guidance literature:

With palladium diacetate; triethylamine; In acetonitrile; at 150 ℃; for 7h;

DOI:10.1016/S0040-4020(01)91149-4

Reference yield: 72.0%

9H-carbazole-1-carbaldehyde (1903-94-2) → 9H-carbazole-1-carboxylic acid (6311-19-9)

Guidance literature:

With sodium hydroxide; dipotassium hydrogenphosphate; potassium dihydrogenphosphate; D-glucose; Aspergillus fumigatus; magnesium sulfate; potassium nitrate; sodium chloride; calcium chloride; In water; for 48h; pH 7.0, further reagent: Pseudomonas aeruginosa;

Reference yield: 58.0%

5,6,7,8-tetrahydro-9H-carbazole-1-carboxylic acid (65764-56-9) → 9H-carbazole-1-carboxylic acid (6311-19-9)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In toluene; for 2h; Heating;

DOI:10.1248/cpb.52.1071

upstream raw materials:

1-aminocarbazole

ethyl carbazole-1-carboxylate

1-carbazol-1-yl-2-phenyl-ethanone

5-ethyl-pyrido[3,2,1-jk]carbazole-4,6-dione

Downstream raw materials:

9H-carbazole

N-[3-(4-methylimidazol-1-yl)-phenyl]-9H-carbazole-1-carboxamide

N-(3-([1,2,4]triazol-4-yl)phenyl)-9H-carbazole-1-carboxamide

2-hydroxy-9H-carbazole-1-carboxylic acid

Refernces

• 1、 Chakraborty,Chowdhury. "Microbial transformation of selected carbazole derivatives". . p. 617 - 620. Retrieved 2007/10/03.
• 2、 Ames, D.E.,Opalko, A.. "PALLADIUM-CATALYSED CYCLISATION OF 2-SUBSTITUTED HALOGENOARENES BY DEHYDROHALOGENATION". . p. 1919 - 1926. Retrieved 2007/10/02.