tert-butyl 4-(3-bromo-2-oxopropyl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(3-bromo-2-oxopropyl)piperidine-1-carboxylate
• CAS No.: 473795-43-6
• Molecular Formula: C13H22BrNO3
• Molecular Weight: 320.22300
• Mol file: 473795-43-6.mol

Synonyms:4-(3-bromo-2-oxopropyl)piperidine-1-carboxylic acid tert-butyl ester;tert-butyl 4-(3-bromo-2-oxopropyl)piperidine-1-carboxylate;4-(3-bromo-2-oxo-propyl)-piperidine-1-carboxylic acid tert-butyl ester;

Chemical Property of tert-butyl 4-(3-bromo-2-oxopropyl)piperidine-1-carboxylate

Chemical Property:

• Boiling Point: 381.6±12.0 °C(Predicted)
• PKA: -1.74±0.40(Predicted)
• PSA: 46.61000
• Density: 1.285±0.06 g/cm3(Predicted)
• LogP: 2.92550

Purity/Quality:

97% ^*data from raw suppliers

tert-butyl4-(3-bromo-2-oxopropyl)piperidine-1-carboxylate 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-(3-bromo-2-oxopropyl)piperidine-1-carboxylate

There total 7 articles about tert-butyl 4-(3-bromo-2-oxopropyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

tert-butyl 4-(3-hydroxy-2-oxopropyl)piperidine-1-carboxylate (1580440-22-7) → tert-Butyl 4-(3-Bromo-2-Oxopropyl)Piperidine-1-Carboxylate (473795-43-6)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; for 3h;

Reference yield: 52.0%

tert-butyl 4-(2-oxopropyl)piperidine-1-carboxylate (206989-54-0) → tert-Butyl 4-(3-Bromo-2-Oxopropyl)Piperidine-1-Carboxylate (473795-43-6)

Guidance literature:

tert-butyl 4-(2-oxopropyl)piperidine-1-carboxylate; With chloro-trimethyl-silane; lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

With phenyltrimethylammonium tribromide; In tetrahydrofuran; at 0 ℃; for 0.5h;

Reference yield:

tert-butyl 4-(2-oxopropyl)piperidine-1-carboxylate (206989-54-0) → tert-Butyl 4-(3-Bromo-2-Oxopropyl)Piperidine-1-Carboxylate (473795-43-6) + 4-(2-(chloromethyl)-2-oxoethyl)piperidine-1-carboxylic acid tert-butyl ester (569667-97-6)

Guidance literature:

tert-butyl 4-(2-oxopropyl)piperidine-1-carboxylate; With chloro-trimethyl-silane; lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

With phenyltrimethylammonium tribromide; In tetrahydrofuran; at 0 ℃; for 1h; Further stages. Title compound not separated from byproducts.;

DOI:10.1002/jhet.5570450131

upstream raw materials:

tert-butyl 4-(2-oxopropyl)piperidine-1-carboxylate

1-(N-tert-butoxycarbonylpiperidin-4-ylidene)propan-2-one

N-tert-butyloxycarbonylpiperidin-4-one

tert-butyl 4-(3-(benzyloxy)-2-oxopropylidene)piperidine-1-carboxylate

Downstream raw materials:

1-azabicyclo[3.2.2]nonan-3-one