Technology Process of tert-butyl 4-(3-(benzyloxy)-2-oxopropylidene)piperidine-1-carboxylate
There total 3 articles about tert-butyl 4-(3-(benzyloxy)-2-oxopropylidene)piperidine-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(3-benzyloxy-2-oxopropyl)phosphonic acid dimethyl ester;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 ℃;
for 0.5h;
N-tert-butyloxycarbonylpiperidin-4-one;
In
tetrahydrofuran; mineral oil;
at 0 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 3 h / 0 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
2.2: 2 h / 0 °C
With
sodium hydride; lithium diisopropyl amide;
In
tetrahydrofuran; n-heptane; ethylbenzene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
1.2: 20 °C
2.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 3 h / 0 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
3.2: 2 h / 0 °C
With
tetra-(n-butyl)ammonium iodide; sodium hydride; lithium diisopropyl amide;
In
tetrahydrofuran; n-heptane; ethylbenzene; mineral oil;
