Carbamic acid, dimethyl-, 4-[(1R)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-nitrophenoxy)prop yl]-3-hydroxyphenyl ester

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Chemical Name:Carbamic acid, dimethyl-, 4-[(1R)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-nitrophenoxy)prop yl]-3-hydroxyphenyl ester
CAS No.:474295-97-1
Molecular Formula:C23H29N3O8
Molecular Weight:475.499
Hs Code.:
Mol file:474295-97-1.mol

Synonyms:

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Chemical Property of Carbamic acid, dimethyl-, 4-[(1R)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-nitrophenoxy)prop yl]-3-hydroxyphenyl ester

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Technology Process of Carbamic acid, dimethyl-, 4-[(1R)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-nitrophenoxy)prop yl]-3-hydroxyphenyl ester

There total 5 articles about Carbamic acid, dimethyl-, 4-[(1R)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-nitrophenoxy)prop yl]-3-hydroxyphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 474296-07-6
Dimethyl-carbamic acid 4-[(R)-1-amino-3-(4-nitro-phenoxy)-propyl]-3-hydroxy-phenyl ester

: 474295-97-1
[1-(4-dimethylcarbamoyloxy-2-hydroxyphenyl)-3-(4-nitrophenoxy)propyl]carbamic acid tert-butyl ester

Guidance literature:: With triethylamine; In methanol; at 20 ℃; for 1h;
DOI:10.1021/ol026418e DOI:10.1016/S0968-0896(03)00452-8

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 474295-97-1
[1-(4-dimethylcarbamoyloxy-2-hydroxyphenyl)-3-(4-nitrophenoxy)propyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 6.49 g / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran; toluene / 1 h / 20 °C

2: 1.91 g / hydrochloric acid / methanol / 18 h / 20 °C

3: 85 percent / triethylamine / methanol / 1 h / 20 °C

With hydrogenchloride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; toluene; 1: Mitsunobu reaction;
DOI:10.1016/S0968-0896(03)00452-8

Reference yield:

: 474295-96-0
[1-(4-dimethylcarbamoyloxy-2-methoxymethoxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester

: 474295-97-1
[1-(4-dimethylcarbamoyloxy-2-hydroxyphenyl)-3-(4-nitrophenoxy)propyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.91 g / hydrochloric acid / methanol / 18 h / 20 °C

2: 85 percent / triethylamine / methanol / 1 h / 20 °C

With hydrogenchloride; triethylamine; In methanol;
DOI:10.1016/S0968-0896(03)00452-8