1(2H)-Quinolinecarboxylic acid, 2-ethyl-3,4-dihydro-4-[[(phenylmethoxy)carbonyl]amino]-6-(trifluorometh yl)-, 1-methylethyl ester, (2R,4S)-

Base Information

Chemical Name:1(2H)-Quinolinecarboxylic acid, 2-ethyl-3,4-dihydro-4-[[(phenylmethoxy)carbonyl]amino]-6-(trifluorometh yl)-, 1-methylethyl ester, (2R,4S)-
CAS No.:474645-99-3
Molecular Formula:C₂₄H₂₇F₃N₂O₄
Molecular Weight:464.485
Hs Code.:
Mol file:474645-99-3.mol

1(2H)-Quinolinecarboxylic acid,
2-ethyl-3,4-dihydro-4-[[(phenylmethoxy)carbonyl]amino]-6-(trifluorometh
yl)-, 1-methylethyl ester, (2R,4S)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1(2H)-Quinolinecarboxylic acid, 2-ethyl-3,4-dihydro-4-[[(phenylmethoxy)carbonyl]amino]-6-(trifluorometh yl)-, 1-methylethyl ester, (2R,4S)-

Chemical Property:

Purity/Quality:

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Technology Process of 1(2H)-Quinolinecarboxylic acid, 2-ethyl-3,4-dihydro-4-[[(phenylmethoxy)carbonyl]amino]-6-(trifluorometh yl)-, 1-methylethyl ester, (2R,4S)-

There total 4 articles about 1(2H)-Quinolinecarboxylic acid, 2-ethyl-3,4-dihydro-4-[[(phenylmethoxy)carbonyl]amino]-6-(trifluorometh yl)-, 1-methylethyl ester, (2R,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 667937-05-5
(3R)-3-(4-trifluoromethylphenylamino)pentanoic acid amide

: 474645-99-3
C₂₄H₂₇F₃N₂O₄

Guidance literature:: Multi-step reaction with 3 steps

1: lithium tert-butoxide / tetrahydrofuran; diethyl ether / -10 - 0 °C

2: sodium tetrahydroborate; magnesium chloride / ethanol; water

3: pyridine / 0 - 20 °C

With pyridine; sodium tetrahydroborate; magnesium chloride; lithium tert-butoxide; In tetrahydrofuran; diethyl ether; ethanol; water;
DOI:10.1016/j.bmcl.2012.04.042

Reference yield:

: 98-56-6
4-chlorobenzotrifluoride

: 474645-99-3
C₂₄H₂₇F₃N₂O₄

Guidance literature:: Multi-step reaction with 5 steps

1: palladium diacetate; caesium carbonate; DavePhos; phenylboronic acid / dichloromethane; toluene / 80 °C

2: sulfuric acid / toluene / 35 °C

3: lithium tert-butoxide / tetrahydrofuran; diethyl ether / -10 - 0 °C

4: sodium tetrahydroborate; magnesium chloride / ethanol; water

5: pyridine / 0 - 20 °C

With pyridine; sodium tetrahydroborate; sulfuric acid; palladium diacetate; caesium carbonate; magnesium chloride; lithium tert-butoxide; DavePhos; phenylboronic acid; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; toluene;
DOI:10.1016/j.bmcl.2012.04.042

Reference yield:

: 474645-97-1
(R)-3-aminopentanenitrile methanesulfonic acid salt

: 474645-99-3
C₂₄H₂₇F₃N₂O₄

Guidance literature:: Multi-step reaction with 5 steps

1: palladium diacetate; caesium carbonate; DavePhos; phenylboronic acid / dichloromethane; toluene / 80 °C

2: sulfuric acid / toluene / 35 °C

3: lithium tert-butoxide / tetrahydrofuran; diethyl ether / -10 - 0 °C

4: sodium tetrahydroborate; magnesium chloride / ethanol; water

5: pyridine / 0 - 20 °C

With pyridine; sodium tetrahydroborate; sulfuric acid; palladium diacetate; caesium carbonate; magnesium chloride; lithium tert-butoxide; DavePhos; phenylboronic acid; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; toluene;
DOI:10.1016/j.bmcl.2012.04.042