474645-97-1

Basic information

• Product Name: (3R)-3-AMINOPENTANENITRILE METHANESULFONATE
• Synonyms: (3R)-3-AMINOPENTANENITRILE METHANESULFONATE;(R)-3-Aminopentanenitrile Methanesulfonic Acid Salt;((R)-2-Cyano-1-ethylethyl)aMMoniuM Methanesulfonate
• CAS NO: 474645-97-1
• Molecular Formula: CH₄O₃S*C₅H₁₀N₂
• Molecular Weight: 194.25
• Product Categories: Chiral Reagents;Intermediates
• Mol File: 474645-97-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 414.7 °C at 760 mmHg
• Flash Point: 204.6 °C
• Appearance: /
• Solubility: Dimethylformamide, DMSO
• CAS DataBase Reference: (3R)-3-AMINOPENTANENITRILE METHANESULFONATE(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-3-AMINOPENTANENITRILE METHANESULFONATE(474645-97-1)
• EPA Substance Registry System: (3R)-3-AMINOPENTANENITRILE METHANESULFONATE(474645-97-1)

Safety Data

• Hazardous Substances Data: 474645-97-1(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Intermediate in the preparation of quinolines.

Upstream product

• 75-75-2 methanesulfonic acid 
• 198493-28-6 (R)-N-tert-butyloxycarbonyl-3-aminopentanenitrile 
• 400090-60-0 (R)-3-aminopentanenitrile 

Downstream Products

• 474645-93-7 (2R,4S)-(2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinolin-4-yl)carbamic acid methyl ester 
• 474645-91-5 (R)-3-((4-(trifluoromethyl)phenyl)amino)pentanenitrile 
• 874502-14-4 C₃₀H₃₃F₉N₆O₂ 
• 874502-20-2 C₃₀H₃₃F₉N₆O₂ 
• 874502-11-1 C₂₉H₃₁F₉N₆O₂ 
• 874502-17-7 C₃₀H₃₃F₉N₆O₂ 
• 474645-99-3 C₂₄H₂₇F₃N₂O₄ 
• 667937-05-5 (3R)-3-(4-trifluoromethylphenylamino)pentanoic acid amide 
• 874501-83-4 C₂₉H₃₁F₉N₆O₂ 
• 880103-60-6 (2R,4S)-4-[(3,5-bis-trifluoromethyl-benzyl)-(2-methyl-2H-tetrazol-5-yl)-amino]-2-ethyl-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester 
• 874501-94-7 C₂₆H₂₅F₉N₆O₂ 
• 1380600-45-2 C₂₉H₂₉F₉N₄O₂ 
• 261947-57-3 [2R,4S]4-(3,5-bis-trifluoromethyl-benzylamino)-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester 
• 874502-26-8 C₂₉H₃₁F₉N₆O₃ 

Relevant articles and documents

Asymmetric synthesis of the cholesteryl ester transfer protein inhibitor torcetrapib

Previously our group reported synthetic efforts used to synthesize kilogram quantities of the cholesteryl ester transfer protein (CETP) inhibitor torcetrapib, 1, via a mid-stage resolution. This account describes research conducted to develop an asymmetri

PREPARATION OF CHIRAL AMINO-NITRILES

A process and intermediates for producing 3-amino nitrites. The process involves resolving an enantiomeric mixture of chiral 3-amino nitrites in the presence of a chiral acid in a solvent system to produce a chiral 3-amino nitrile salt. The process may fu

Intermediates of CETP inhibitors

This invention relates to intermediates useful in the preparation of CETP inhibitors and methods of preparation thereof.