[4-(acetyloxy)-3-methoxyphenyl]methanediyl diacetate

Base Information

• Chemical Name: [4-(acetyloxy)-3-methoxyphenyl]methanediyl diacetate
• CAS No.: 6301-73-1
• Molecular Formula: C14H16 O7
• Molecular Weight: 296.277
• Mol file: 6301-73-1.mol

Synonyms:Methanediol,(4-acetyloxy-3-methoxyphenyl)-, diacetate (9CI);4-(Diacetoxymethyl)-2-methoxyphenyl acetate; 4-Acetoxy-3-methoxybenzaldehydediacetate; 4-Acetoxy-3-methoxyphenylmethanediol diacetate;4-Hydroxy-3-methoxybenzaldehyde diacetate; NSC 42598

Chemical Property of [4-(acetyloxy)-3-methoxyphenyl]methanediyl diacetate

Chemical Property:

• Vapor Pressure: 6.46E-06mmHg at 25°C
• Boiling Point: 378.1°Cat760mmHg
• Flash Point: 165.2°C
• Density: 1.228g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [4-(acetyloxy)-3-methoxyphenyl]methanediyl diacetate

There total 4 articles about [4-(acetyloxy)-3-methoxyphenyl]methanediyl diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

acetic anhydride (108-24-7) + vanillin (121-33-5,8014-42-4) → 1,1-diacetoxy-1-(4-acetoxy-3-methoxyphenyl)methane (6301-73-1)

Guidance literature:

In neat (no solvent); at 20 ℃; for 0.0666667h; chemoselective reaction; Green chemistry;

DOI:10.4067/S0717-97072016000100007

Reference yield: 82.0%

vanillin acetate (881-68-5) + acetic anhydride (108-24-7) → 1,1-diacetoxy-1-(4-acetoxy-3-methoxyphenyl)methane (6301-73-1)

Guidance literature:

With aluminum oxide; phosphorus pentaoxide; at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2007.02.090

Reference yield: 68.0%

acetic anhydride (108-24-7) + vanillin (121-33-5,8014-42-4) → vanillin acetate (881-68-5) + 1,1-diacetoxy-1-(4-acetoxy-3-methoxyphenyl)methane (6301-73-1)

Guidance literature:

aluminum(III) hydrogen sulfate; for 0.5h; Heating;

DOI:10.1134/S1070428007060085

upstream raw materials:

acetic anhydride

vanillin

3-methoxy-4-(phenylmethoxy)benzaldehyde

vanillin acetate

Downstream raw materials:

vanillin acetate

vanillin

1-acetoxy-5-chloro-4-diacetoxymethyl-2-methoxy-benzene

Refernces

• 1、 Kang, Li Q.,Cai, Yue Q.,Cheng, Lin. "Solvent-free catalytic preparation of 1,1-diacetates using a silica-supported functional ionic liquid as catalyst". . p. 247 - 249. Retrieved 2013/07/27.
• 2、 Boroujeni, Kaveh Parvanak. "Polystyrene-supported, Al(OTf)3-catalyzed chemoselective synthesis of acylals from aldehydes". experimental part. p. 277 - 284. Retrieved 2011/03/20.