Technology Process of 2,4-Heptadienoic acid, 7-phenyl-, ethyl ester, (2E,4E)-
There total 5 articles about 2,4-Heptadienoic acid, 7-phenyl-, ethyl ester, (2E,4E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
ethyl (2E)-5-phenylpent-2-enoate;
With
diisobutylaluminium hydride;
In
tetrahydrofuran; hexane;
at -78 - -40 ℃;
for 1.25h;
Inert atmosphere;
ethyl (triphenylphosphoranylidene)acetate;
With
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
dimethyl sulfoxide;
at 70 ℃;
for 0.666667h;
Inert atmosphere;
DOI:10.1021/ol403415z
- Guidance literature:
-
diethoxyphosphoryl-acetic acid ethyl ester;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 ℃;
for 0.5h;
(2E)-5-phenyl-2-pentenal;
In
tetrahydrofuran; mineral oil;
at -78 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
1.2: 1 h / -78 °C
2.1: diisobutylaluminium hydride / toluene; hexane / 6 h / -78 °C
2.2: 20 °C / pH 1
2.3: 15 h / 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
3.2: 1 h / -78 °C
With
sodium hydride; diisobutylaluminium hydride;
In
tetrahydrofuran; hexane; toluene; mineral oil;
