Hexanoic acid, 3-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]-2-(2-hydroxyethyl)-5-methyl-, (4-methoxyphenyl)methyl ester, (2S,3R)-

Base Information

Chemical Name:Hexanoic acid, 3-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]-2-(2-hydroxyethyl)-5-methyl-, (4-methoxyphenyl)methyl ester, (2S,3R)-
CAS No.:477587-08-9
Molecular Formula:C21H35NO5S
Molecular Weight:413.579
Hs Code.:
Mol file:477587-08-9.mol

Synonyms:

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Chemical Property of Hexanoic acid, 3-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]-2-(2-hydroxyethyl)-5-methyl-, (4-methoxyphenyl)methyl ester, (2S,3R)-

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Technology Process of Hexanoic acid, 3-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]-2-(2-hydroxyethyl)-5-methyl-, (4-methoxyphenyl)methyl ester, (2S,3R)-

There total 4 articles about Hexanoic acid, 3-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]-2-(2-hydroxyethyl)-5-methyl-, (4-methoxyphenyl)methyl ester, (2S,3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 477587-07-8
5-methyl-3-(2-methylpropane-2-sulfinylamino)-2-(2-(triisopropylsilanyloxy)ethyl)hexanoic acid 4-methoxybenzyl ester

: 477587-08-9
2-(2-hydroxyethyl)-5-methyl-3-(2-methylpropane-2-sulfinylamino)hexanoic acid 4-methoxybenzyl ester

Guidance literature:: With pyridine hydrogenfluoride; In tetrahydrofuran; for 24h;
DOI:10.1021/jo025957u

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 477587-08-9
2-(2-hydroxyethyl)-5-methyl-3-(2-methylpropane-2-sulfinylamino)hexanoic acid 4-methoxybenzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrabutylammonium iodide / acetone / 24 h / Heating

2.1: 71 percent / imidazole / tetrahydrofuran / 24 h / 20 °C

3.1: lithium diisopropylamide / tetrahydrofuran / 0.5 h / -78 °C

3.2: titanium triisopropoxide chloride / tetrahydrofuran / 0.5 h / -78 °C

3.3: tetrahydrofuran / 3 h / -78 °C

4.1: 73 percent / HF*pyridine / tetrahydrofuran / 24 h

With 1H-imidazole; tetra-(n-butyl)ammonium iodide; pyridine hydrogenfluoride; lithium diisopropyl amide; In tetrahydrofuran; acetone;
DOI:10.1021/jo025957u

Reference yield:

: 477587-04-5
4-hydroxybutyric acid 4-methoxybenzyl ester

: 477587-08-9
2-(2-hydroxyethyl)-5-methyl-3-(2-methylpropane-2-sulfinylamino)hexanoic acid 4-methoxybenzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 71 percent / imidazole / tetrahydrofuran / 24 h / 20 °C

2.1: lithium diisopropylamide / tetrahydrofuran / 0.5 h / -78 °C

2.2: titanium triisopropoxide chloride / tetrahydrofuran / 0.5 h / -78 °C

2.3: tetrahydrofuran / 3 h / -78 °C

3.1: 73 percent / HF*pyridine / tetrahydrofuran / 24 h

With 1H-imidazole; pyridine hydrogenfluoride; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/jo025957u