methyl 3-(3-nitrophenyl)-3-oxopropanoate

Base Information

• Chemical Name: methyl 3-(3-nitrophenyl)-3-oxopropanoate
• CAS No.: 83256-99-9
• Molecular Formula: C10H9 N O5
• Molecular Weight: 223.185
• Mol file: 83256-99-9.mol

Synonyms:Methyl3-nitro-b-oxobenzenepropanoate; NSC 93929

Chemical Property of methyl 3-(3-nitrophenyl)-3-oxopropanoate

Chemical Property:

• Vapor Pressure: 0.00124mmHg at 25°C
• Boiling Point: 298.9°Cat760mmHg
• Flash Point: 127.2°C
• Density: 1.318g/cm³

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 3-(3-nitrophenyl)-3-oxopropanoate

There total 7 articles about methyl 3-(3-nitrophenyl)-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-nitro-benzaldehyde (99-61-6) + methyl diazoacetate (6832-16-2) → 3-(3-nitrophenyl)-3-oxopropionic acid methyl ester (83256-99-9)

Guidance literature:

yttria-stabilized zirconia; In 1,2-dichloro-ethane; for 20h; Heating;

DOI:10.1081/SCC-120028644

Reference yield: 73.0%

syn-benzaldehyde oxime (932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2) + methyl 3-(3-nitrophenyl)propiolate (7515-22-2) → 3-(3-nitrophenyl)-3-oxopropionic acid methyl ester (83256-99-9)

Guidance literature:

With sodium hydride; In 1,4-dioxane; N,N-dimethyl-formamide; 1.) r.t., 0.5 h, 2.) 0.5 h;

DOI:10.1021/jo00084a051

Reference yield: 67.56%

ethyl 3-nitrobenzoate (618-98-4) + ethyl acetate (141-78-6) → 3-(3-nitrophenyl)-3-oxopropionic acid methyl ester (83256-99-9)

Guidance literature:

ethyl acetate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

ethyl 3-nitrobenzoate; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

upstream raw materials:

syn-benzaldehyde oxime

methyl 3-(3-nitrophenyl)propiolate

acetic acid methyl ester

ethyl 3-nitrobenzoate

Downstream raw materials:

3-(3-nitrophenyl)isoxazol-5(4H)-one

3-(3-nitrophenyl)-5-chloroisoxazole