Technology Process of 2H-1-Benzopyran-2-one,
8-[(S)-[3,5-dimethoxy-4-(phenylmethoxy)phenyl]-(2R)-oxiranylmethoxy]-
7-(phenylmethoxy)-
There total 10 articles about 2H-1-Benzopyran-2-one,
8-[(S)-[3,5-dimethoxy-4-(phenylmethoxy)phenyl]-(2R)-oxiranylmethoxy]-
7-(phenylmethoxy)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
threo-(1R,2R)-1-(4'-benzyloxy-3',5'-dimethoxyphenyl)-3-O-tosyl-1,2-glycol;
With
potassium carbonate;
In
methanol;
at 20 ℃;
for 3h;
7-Benzyloxy-8-hydroxycoumarin;
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
for 24h;
DOI:10.1016/S0957-4166(02)00482-2
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 97 percent / pyridine / CH2Cl2 / 24 h / 20 °C
2.1: 79 percent / AlCl3 / 2 h / 160 °C
3.1: 94 percent / K2CO3 / acetone / 24 h / 20 °C
4.1: 94 percent / aq. H2O2; aq. NaOH / dioxane / 0.33 h / 10 °C
5.1: K2CO3 / methanol / 3 h / 20 °C
5.2: PPh3; DIAD / tetrahydrofuran / 24 h / 20 °C
With
pyridine; sodium hydroxide; aluminium trichloride; dihydrogen peroxide; potassium carbonate;
In
1,4-dioxane; methanol; dichloromethane; acetone;
4.1: Baeyer-Villiger oxidation / 5.2: Mitsunobu reaction;
DOI:10.1016/S0957-4166(02)00482-2
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 79 percent / AlCl3 / 2 h / 160 °C
2.1: 94 percent / K2CO3 / acetone / 24 h / 20 °C
3.1: 94 percent / aq. H2O2; aq. NaOH / dioxane / 0.33 h / 10 °C
4.1: K2CO3 / methanol / 3 h / 20 °C
4.2: PPh3; DIAD / tetrahydrofuran / 24 h / 20 °C
With
sodium hydroxide; aluminium trichloride; dihydrogen peroxide; potassium carbonate;
In
1,4-dioxane; methanol; acetone;
3.1: Baeyer-Villiger oxidation / 4.2: Mitsunobu reaction;
DOI:10.1016/S0957-4166(02)00482-2
